HLA‐lacking clones in aplastic anaemia: Adaptive or maladaptive?

Abstract

HLA loss represents the result of immune forces shaping bone marrow clonal dynamics in immune aplastic anaemia. Human leukocyte antigen (HLA)‐deficient clones may rescue haematopoiesis by evading immune attacks, potentially guiding treatment strategies.Commentary on: Zaimoku et al. Haematopoietic regeneration by HLA‐A*0206‐deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19712.