HLA frequencies and associations in cystic fibrosis

Abstract

Cystic fibrosis (CF) is classically attributed to the dysfunction of the single CF transmembrane conductance regulator gene. The incidence of human leukocyte antigen (HLA) polymorphisms in different CF-associated diseases raises the question of an unequal distribution of HLA genotypes in CF. This study aimed to evaluate HLA gene frequencies and possible associations in CF patients compared with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, performed by intermediate resolution typing using Luminex sequence-specific oligonucleotide, and epitope counts were similar in 340 CF patients when compared with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem to influence susceptibility to CF. Whether HLA plays a role in the severity of CF disease needs to be investigated.

Association of HLA-DR Alleles With Pulmonary Cystic Fibrosis

“…Although early studies indicated an association between HLA-DR4 and CF [27], our current data that shown there were no signi cant differences in the distribution of the alleles in 50 Iranian CF patients compared with the control group is in line with other, more recent, studies where no association between HLA class 1 and 2 with CF have been observed [6,[30][31][32][33][34][35][36]. Future studies should examine whether there is any link to disease severity.…”

The Cystic Fibrosis Transmembrane Regulator Controls Tolerogenic Responses to Food Allergens in Mice and Humans

“…In addition, the HLA-DQ gene region, especially DQ6, was linked to peanut allergy in two comprehensive studies (Hong et al, 2015;Madore et al, 2013). HLA studies performed on pwCF revealed increased frequencies of DR4 and DR7 alleles compared to controls (Aron et al, 2012), however, findings were not reproduced in a large study (Adriaanse et al, 2014). Here, we characterized the human leukocyte antigen (HLA) class II locus of pwCF with IgG reactivity to peanut allergens.…”