HLA‐class II alleles in patients with drug‐resistant pulmonary tuberculosis in Kazakhstan

Abstract

The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Some studies have reported that HLA class II genes play a strong role in severe cases of pulmonary tuberculosis (PTB) in several populations. Thus the aim of the study was to compare the HLA-class II alleles of patients with drug resistant tuberculosis with those of healthy controls from the same ethnic group in Kazakhstan. The aim of the present study was to evaluate the correlation of HLA-class II alleles by patients with drug resistant tuberculosis and the healthy controls of the same ethnic group in Kazakhstan. The HLA-class II alleles of 76 patients with tuberculosis (TB) and 157 healthy volunteers were investigated using sequence-based typing (SBT)-method. HLA-DQA1*03:02 HLA-DRB1*08:01 and DRB1*08:03 occurred more frequently (P = 0.05) in patients with drug resistant tuberculosis than in controls. We observed a possible association between certain HLA alleles and TB that are specific for the Kazakh population. Further studies are needed to confirm our findings using a larger number of patients with drug resistant tuberculosis.

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

“…For example, DRB1*15 has been reported to be associated with the susceptibility of TB in various ethnic groups such as Indian (Rajalingam et al, 1996;Ravikumar et al, 1999;Stroup DF et al, 2000;Sriram et al, 2001;Mishra et al, 2014;Kuranov et al, 2014), Mexican (Teran et al, 1999), Chinese (Shi et al, 2011), Polish (Dubaniewicz et al, 2005) and Korean (Kim et al, 2005). DRB1*16 is reported to have a positive association with the susceptibility to tuberculosis in Polish population (Dubaniewicz et al, 2005), but a negative association in the Sahariya tribe of North Central India (Mishra et al, 2014).…”

“…Some studies have identified a positive association between the DRB1 alleles and TB across geographical locations-DRB1*15 in the Sahariya tribe (Mishra et al, 2014), DRB1*0801 and DRB1*0803 in Kazakhstan (Kuranov et al, 2014), DRB1*15 in Chinese (Shi et al, 2011), DRB1*14 in Portuguese (Duarte et al, 2011), DRB1*0803 in Korean (Kim et al, 2005), DRB1*16 in Polish (Dubaniewicz et al, 2000), DRB1*04 and DRB1*11 in Syrian (Harfouch and Daher, 2008), and DRB1*07 in Iranian populations (Amirzargar et al, 2004). However, other studies have reported no association.…”

Disseminated Mycobacterium Bovis Infection in an Immunodeficient Child: A Case with Cutaneous Lesions

“…The susceptibility to tuberculosis is controlled genetically in different populations. The DRB1*08:03 allele may be associated with tuberculosis progression and may affect the development of drug resistance and recurrent disease in Kazakhs [6]. Although the clinical diagnosis of SCID was the primary reason for the clinical course, genetic factors also may have contributed to the poor prognosis.…”

The Relationship of HLA-DQ Alleles with Tuberculosis Risk: A Meta-analysis

“…Forty-nine articles were excluded after acquiring and reading the full text in detail (five studies with duplicate/overlapping articles, four studies without data of interest or raw data, six studies that were reviews, two articles in Russian language, and 32 studies that were about HLA-DRB1). In the end, a total of 12 studies were available for this meta-analysis, among which, all of them were about DQB1 [2,[10][11][12][13][19][20][21][22][23][24][25], and 6 studies were about DQA1 [10,13,19,21,24,25].…”