<scp>H</scp>uman parechovirus central nervous system infection: A rare cause of neonatal encephalitis

Leow, Jia Yi; Gupta, Rajat Das; Sohal, Aman

doi:10.1111/jpc.13025

Cited by 5 publications

(5 citation statements)

References 4 publications

(7 reference statements)

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“…Distinctive supratentorial white matter and callosal diffusion abnormality on MR imaging is shared between ours and other published series. 3,12,13,[15][16][17] Thalamic involvement and sparing of the posterior fossa structures have been reported variably but were universally present in our cases. 12,18 T1-and T2-shortening foci branching along the distribution of the deep medullary veins is consistent with examples presented by Belcastro et al 13 and Verboon-Maciolek et al 9 but has not been consistent across studies.…”

Section: Discussionmentioning

confidence: 50%

Human Parechovirus Meningoencephalitis: Neuroimaging in the Era of Polymerase Chain Reaction–Based Testing

Sarma

Hanzlik

Krishnasarma

et al. 2019

AJNR Am J Neuroradiol

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Human parechovirus infection is an increasingly recognized cause of neonatal meningoencephalitis. We describe characteristic clinical features and brain MR imaging abnormalities of human parechovirus meningoencephalitis in 6 infants. When corroborated by increasingly available polymerase chain reaction-based testing of the CSF, the distinctive MR imaging appearance may yield a specific diagnosis that obviates costly and time-consuming further clinical evaluation. In our study, infants with human parechovirus presented in the first 35 days of life with seizures, irritability, and sepsis. MR imaging consistently demonstrated low diffusivity within the thalami, corpus callosum, and subcortical white matter with a frontoparietal predominance. T1 and T2 shortening connoting white matter injury along the deep medullary veins suggests venous ischemia as an alternative potential pathogenetic mechanism to direct neuroaxonal injury.

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Section: Discussionmentioning

confidence: 50%

Human Parechovirus Meningoencephalitis: Neuroimaging in the Era of Polymerase Chain Reaction–Based Testing

Sarma

Hanzlik

Krishnasarma

et al. 2019

AJNR Am J Neuroradiol

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“…Closely related to enteroviruses, human parechoviruses comprise a genus within the Picornaviridae family. 1,2,3 Up to 19 different parechovirus genotypes have been identified with varying clinical presentations. 3,4 Transmission is predominantly via the oral-faecal route.…”

Section: Discussionmentioning

confidence: 99%

“…1,2,3 Up to 19 different parechovirus genotypes have been identified with varying clinical presentations. 3,4 Transmission is predominantly via the oral-faecal route. 1 Although other genotypes are often associated with mild symptoms, HPeV-3 is an emerging pathogen that has been increasingly recognized as a causative agent of neonatal meningoencephalitis and sepsis.…”

Section: Discussionmentioning

confidence: 99%

“…5 Human parechovirus-3 infection may be confirmed via reverse transcriptase real-time polymerase chain reaction (RT-PCR) using stool, blood, respiratory samples or CSF, while characteristic imaging plays a supportive role in diagnosis. 1,3 Cranial ultrasound findings are non-specific and can be insensitive early in the disease course. 2 Parechovirus meningoencephalitis is best evaluated with MRI.…”

Section: Discussionmentioning

confidence: 99%

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Human parechovirus meningoencephalitis

et al. 2023

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Human parechovirus-3 (HPeV-3) infection is one of the differential diagnoses of neonatal meningoencephalitis. A 13-day-old full-term female neonate presented with a seizure. Brain MRI showed classic imaging findings of the meningoencephalitis which was confirmed on cerebrospinal fluid analysis.Contribution: The HPeV-3 is an emerging pathogen for neonatal meningoencephalitis. The case in this study is unique with classic imaging findings, which are not routinely encountered in day-to-day practice. This case raises reader awareness.

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“…Usually, Parechovirus HPeV3 encephalitis is seen in neonates, especially premature ones. Neonates are likely, due to their immune status carry a guarded prognosis due to its impact on the neurodevelopmental outcome [4][5][6]. Key features of Neuroimaging include MRI T2 hyperintensity and corresponding diffusion restriction involving the periventricular and subcortical white matter, corpus callosum, and thalami, and most often symmetric [4].…”

Section: Discussionmentioning

confidence: 99%

Novel Presentation of Parechovirus Encephalitis in Children: Two Unique Cases

Pandit¹,

Pandit²,

Goyal³

et al. 2022

Cureus

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Human Parechovirus encephalitis is an uncommon infection. Very few of the cases have been reported in the literature so far. These reports are mainly about neonatal encephalitis, primarily affecting preterm neonates. Parechovirus encephalitis in otherwise healthy pediatric populations is a rare entity. Here, we present two unique pediatric cases secondary to Parechovirus infection, one with hemidystonia and another with acute onset of altered mental status, confusion, and headache.

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Human parechovirus central nervous system infection: A rare cause of neonatal encephalitis

Cited by 5 publications

References 4 publications

Human Parechovirus Meningoencephalitis: Neuroimaging in the Era of Polymerase Chain Reaction–Based Testing

Human Parechovirus Meningoencephalitis: Neuroimaging in the Era of Polymerase Chain Reaction–Based Testing

Human parechovirus meningoencephalitis

Novel Presentation of Parechovirus Encephalitis in Children: Two Unique Cases

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