GRP78 improves the therapeutic effect of mesenchymal stem cells on hemorrhagic shock‐induced liver injury: Involvement of the NF–кB and HO‐1/Nrf‐2 pathways
Jiahui Han,
Di Jia,
Hao Yao
et al.
Abstract:Mesenchymal stem cells (MSCs) are a popular cell source for repairing the liver. Improving the survival rate and colonization time of MSCs may significantly improve the therapeutic outcomes of MSCs. Studies showed that 78‐kDa glucose‐regulated protein (GRP78) expression improves cell viability and migration. This study aims to examine whether GRP78 overexpression improves the efficacy of rat bone marrow‐derived MSCs (rBMSCs) in HS‐induced liver damage. Bone marrow was isolated from the femurs and tibias of rat… Show more
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