GC models for separation optimization in pressure‐tunable tandem capillary columns operated isothermally

Abstract

In the previous part of this study, a significant improvement of the fundamental relationships that control GC resolution in a pressure-tunable assembly operating in isothermal conditions inside a single oven was made. A theoretical approach for the correct choice of the working temperature was proposed for the first time. In this second part of our report, a new interfacing device has been proposed for a rapid and reliable alignment of the two columns at the midpoint junction. Moreover, the results of a series of experimental tests have confirmed the validity of the proposed mathematical models.

Pressure Tuning of First Dimension Columns in Comprehensive Two-Dimensional Gas Chromatography

“…This essentially represents the knowledge base established to the end of 2005, when PT apparently came to a halt. Recently, the mathematical background to coupled-column separation based on thermodynamic interactions was reported. , A further account of selectivity dependence by using PT was reported recently . It may be a coincidence that recent developments in multidimensional gas chromatography (MDGC) and comprehensive two-dimensional gas chromatography (GC × GC) have reduced the popularity of pressure tuning in GC; the goals of PT GC, MDGC, and GC × GC are all focused on improved separation of mixtures.…”