<scp>GATA</scp> binding protein 3 expression is present in primitive patterns of yolk sac tumours but is not expressed by differentiated variants

Schuldt, Maolly; Rubio, Ana Martínez; Preda, Ovidiu; Nogales, Francisco F.

doi:10.1111/his.12776

Cited by 17 publications

(10 citation statements)

References 9 publications

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“…CK7 and EMA are consistently positive in CCC, with most studies showing these markers to be negative in YST . However, although this is true for the classical microcystic–reticular pattern of YST, strong and heterogeneous expression for CK7 and EMA occurred in glandular YST in more than half our cases.…”

Section: Discussioncontrasting

confidence: 56%

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Germ cell tumour growth patterns originating from clear cell carcinomas of the ovary and endometrium: a comparative immunohistochemical study favouring their origin from somatic stem cells

et al. 2017

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There is considerable immunophenotypical overlap between the two components in these mixed neoplasms, and a panel of markers should be used to facilitate the distinction. We propose that OCT4-expressing somatic cancer cells differentiate into GCT and represent spontaneously induced pluripotent stem cells, possibly conditioned by age-related epigenetic factors. These neoplasms have features of prepubertal type GCT showing lack of 12p gain, preponderance of YST and coexistence with immature neuroectoderm. However, there may also be undifferentiated stem cell areas with embryoid bodies, of the type seen in postpubertal testicular GCT, but lacking a complete embryonal carcinoma immunophenotype.

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Section: Discussioncontrasting

confidence: 56%

“…GATA3 is not expressed typically by CCC, but has been proposed as a marker of classical YST; however, glandular YST is usually negative . This marker was positive in only two of 10 cases of glandular YSTs in our study; there was also focal expression in two cases of CCC.…”

Section: Discussionmentioning

confidence: 99%

Germ cell tumour growth patterns originating from clear cell carcinomas of the ovary and endometrium: a comparative immunohistochemical study favouring their origin from somatic stem cells

et al. 2017

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“…All glandular variants were also negative; in a recent study, GATA3 was only positive in the 'usual' type of primitive extra-embryonal YST patterns (reticular-microcystic) while glandular, hepatoid and solid areas were negative. 22 In six cases in our series, the neoplasms comprised pure YSTs with no somatic epithelial component (in one case an endometriotic cyst was present in the same ovary). Given that four of these exhibited a predominantly glandular morphology, we speculate that an epithelial element may have been present originally and been totally overgrown by the YST component.…”

Section: Discussionmentioning

confidence: 68%

“…All the eight cases in our study where GATA3 was performed were negative, including one case of a ‘usual’ and one of a hepatoid variant. All glandular variants were also negative; in a recent study, GATA3 was only positive in the ‘usual’ type of primitive extra‐embryonal YST patterns (reticular‐microcystic) while glandular, hepatoid and solid areas were negative …”

Section: Discussionmentioning

confidence: 91%

Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours

2016

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Pathologists should be aware of the association between YST and an epithelial neoplasm, the former probably arising from the latter through a process of neometaplasia/retrodifferentiation. Those rare gynaecological pure glandular YSTs in adults may arise secondary to total overgrowth of an epithelial neoplasm. Pathologists need a high index of suspicion to diagnose the YST component, as the morphology is characteristically of a glandular variant with marked morphological overlap with adenocarcinomas. There is also often significant immunophenotypical overlap with epithelial neoplasms, as the YST component may be positive with epithelial membrane antigen (EMA), BerEP4 and cytokeratin 7 (CK7), as well as YST markers. We propose the term 'somatically derived YSTs' for these neoplasms and suggest unification of the terminology between different sites where such neoplasms occur.

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“…The possible reason is that we found a yolk sac differentiation area in case 1, which may lead to the expression of SALL4. Furthermore, all three cases were positive for CK7, with most studies showing these markers to be negative in YST, suggesting that this kind of tumor has a similarity to conventional ovarian epithelial tumors [15]. In addition, OCT3/4 expression has been reported only in high-grade immature ovarian teratomas [16].…”

Section: Discussionmentioning

confidence: 99%

Alpha-fetoprotein (AFP)-producing epithelial ovarian carcinoma (EOC): a retrospective study of 27 cases

Chen

Wang

Cao

et al. 2021

Arch Gynecol Obstet

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Objective The aim of the study was to investigate the relative risk factors associated with the prognosis and effective treatments of alpha-fetoprotein (AFP)-producing epithelial ovarian carcinoma (EOC). Method We presented three cases of AFP-producing EOC and performed a brief review to summarize the clinicopathological features and prognostic factors of 24 cases that have been previously reported. We evaluated the correlations among prognostic and clinical parameters, such as stage, pathology and chemotherapy regimens. In addition, a retrospective review of these 27 cases was conducted, and survival curves were estimated using the Kaplan–Meier method. Results The patients were aged between 23 and 77 years. The median overall survival was 10 months, and ten (37.04%) patients died within 18 months. We compared the overall mean survival times of all patients in different stages, and the results suggest that the postoperative pathological staging is hardly correlated with prognosis ( P = 0.76). There was a correlation between pathology and prognosis ( P = 0.0018). The mean survival time was longer for patients who had undergone chemotherapy than for those without chemotherapy (14.88 vs 0.65 months) ( P < 0.0001). Moreover, although patients had a good response to the regimens for PEB and TC ( P = 0.004), there was no significant difference between PEB and TC ( P = 0.386). Conclusions AFP-producing EOC is uncommon and regarded as an extremely malignant type of tumor. Patients with chemotherapy may have a longer survival time; additionally, PEB and TC may be an optimal selection for this kind of tumor. Further large-scale studies are needed to confirm our findings.

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GATA binding protein 3 expression is present in primitive patterns of yolk sac tumours but is not expressed by differentiated variants

Cited by 17 publications

References 9 publications

Germ cell tumour growth patterns originating from clear cell carcinomas of the ovary and endometrium: a comparative immunohistochemical study favouring their origin from somatic stem cells

Germ cell tumour growth patterns originating from clear cell carcinomas of the ovary and endometrium: a comparative immunohistochemical study favouring their origin from somatic stem cells

Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours

Alpha-fetoprotein (AFP)-producing epithelial ovarian carcinoma (EOC): a retrospective study of 27 cases

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