FT‐ICR

Abstract

Fourier transform ion cyclotron resonance (FT‐ICR) mass spectrometry has become an increasingly significant technique within recent years. The inherently ultrahigh resolution and mass accuracy allow unequivocal assignments of elemental composition to be made for biomolecules. Structural elucidation can be conducted through tandem mass spectrometry experiments. With the advent of electrospray ionization (ESI), FT‐ICR mass spectrometry has become a powerful tool for the investigation of biological macromolecules, including aspects of noncovalent interactions.