<scp>FIGO</scp> Good Practice Recommendations on the use of progesterone in the management of recurrent first‐trimester miscarriage

Shehata, Hassan; Elfituri, Abdullatif; Doumouchtsis, Stergios K.; Zini, Mudiaga Eseajeberuo; Ali, Amanda; Jan, Haider; Ganapathy, Ramesh; Divakar, Hema; Hod, Moshe

doi:10.1002/ijgo.14717

Cited by 6 publications

(2 citation statements)

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“…Local reduced 1,25(OH) 2 D 3 appeared to be closely associated with impaired activation of vitamin D pathways in the placenta. It is worth considering whether vaginal administration of vitamin D, and/or in combination with progesterone [ 35 ] could have a beneficial impact on preventing spontaneous miscarriage, such as luteal-phase support during in vitro fertilization (IVF). Besides, our findings provided insights into one potential factor contributing to the etiology of this condition.…”

Section: Discussionmentioning

confidence: 99%

CPY27B1-related vitamin D deficiency contributes to the impaired function of CD4+T cells in Recurrent spontaneous miscarriage

Yue,

Ma,

Wang

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

CPY27B1-related vitamin D deficiency contributes to the impaired function of CD4+T cells in Recurrent spontaneous miscarriage

Yue,

Ma,

Wang

et al. 2024

Heliyon

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“…This narrative review aims to propose a global holistic approach in the absence of evidence-based guidance, building upon the authors' paper on FIGO Good Practice Recommendations on the use of progesterone in the management of recurrent first-trimester miscarriage. 1 Graded recommendations based on the best available evidence are presented, encompassing the definition of RM, initial and additional investigations, and management options. This academic review underscores the need for standardized guidelines and further research to enhance the management of couples with RM.…”

Section: Introductionmentioning

confidence: 99%

Managing couples with recurrent miscarriage: A narrative review and practice recommendations

Ali

Elfituri

Doumouchtsis

et al. 2023

Intl J Gynecology & Obste

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There is significant variation in practice when managing couples with recurrent miscarriage (RM), with guidelines differing on the definition of RM, recommended investigations, and treatment options. In the absence of evidence‐based guidance, and following on from a paper by the authors—FIGO Good Practice Recommendations on the use of progesterone in the management of recurrent first‐trimester miscarriage—this narrative review aims to propose a global holistic approach. We present graded recommendations based on best available evidence.

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Association between the duration of progesterone supplementation treatment and premature neonates outcomes: A retrospective cohort study

Kazemi Aski,

Sharami,

KabodMehri

et al. 2023

Health Science Reports

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Background and AimsPreterm birth (PTB) is the leading cause of perinatal mortality and morbidity, progesterone is one of the main hormones to maintain a normal pregnancy. However, there are still conflicting results regarding using progesterone supplementation to prevent PTB and improve neonatal outcomes. The length of treatment with progesterone supplementation is also one of the challenges ahead, so the present study was conducted to investigate the relationship between the duration of progesterone supplementation treatment and neonatal outcomes.MethodsThis retrospective cohort study was conducted on pregnant women at risk of PTB and who have taken progesterone supplementation. They were asked about the length of treatment with progesterone supplements and finally, the neonatal outcomes of these women were measured.ResultsA total of 265 pregnant women who met the inclusion criteria were included in this study and the subjects were divided into two groups that received progesterone <12 weeks and received progesterone ≥12. In the group of women receiving progesterone with a treatment duration of ≥12 weeks, the rate of preterm labor, respiratory distress syndrome, low birth weight, and the need for hospitalization were significantly lower than in the group receiving progesterone with a treatment duration of ≥12 weeks.ConclusionProgesterone administration for longer than 12 weeks in women at risk of PTB can improve neonatal outcomes.

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FIGO Good Practice Recommendations on the use of progesterone in the management of recurrent first‐trimester miscarriage

Abstract: Data availabilityData sharing not applicable for this article as no datasets were generated or analyzed during the current study.

Cited by 6 publications

References 45 publications

CPY27B1-related vitamin D deficiency contributes to the impaired function of CD4+T cells in Recurrent spontaneous miscarriage

CPY27B1-related vitamin D deficiency contributes to the impaired function of CD4+T cells in Recurrent spontaneous miscarriage

Managing couples with recurrent miscarriage: A narrative review and practice recommendations

Association between the duration of progesterone supplementation treatment and premature neonates outcomes: A retrospective cohort study

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