EPR‐based oximetric imaging: a combination of single point‐based spatial encoding and T₁ weighting

Abstract

Using the single-point imaging modality, R -based oximetry imaging with useful spatial and oxygen resolutions for small animals was demonstrated.

Development of a fast‐scan EPR imaging system for highly accelerated free radical imaging

“…Therefore, major efforts were devoted to accelerate the EPR image acquisition. On par with key advances in pulsed EPR imaging, 3,10,29 Overhauser effect-based MRI, 13,[30][31][32] and development of rapid scan approaches, 4,8,33,34 traditional CW with field modulation and phase-sensitive detection has undergone major improvements. Pulsed EPR image modality allows functional (oxygen map) images of legs of living mice with matrices of 31 × 31 pixels and submillimeter resolution to be obtained in 264 seconds, 3 or for 3D imaging in vivo, the scan time is under 10 minutes and resolution is 1.4 mm to 2 mm.…”

“…Pulsed EPR image modality allows functional (oxygen map) images of legs of living mice with matrices of 31 × 31 pixels and submillimeter resolution to be obtained in 264 seconds, 3 or for 3D imaging in vivo, the scan time is under 10 minutes and resolution is 1.4 mm to 2 mm. 29 Overhauser effect-based MRI allows increased resolution due to intrinsic advantages of acquiring proton MRI signal. Resolution of about 0.6 mm was achieved in a matrix of 64 × 64 and FOV of 40 × 40 mm in 4.2 minutes 13 or 1.6 mm in 8.4 seconds using functional nitroxides as spin probes.…”

Multimodal Functional Imaging for Cancer/Tumor Microenvironments Based on MRI, EPRI, and PET

“…EPR oxymetry techniques for in vivo oxygen mapping use several EPR based imaging modalities combined with an i.v. injectable nontoxic paramagnetic probe [59][60][61][62][63][64][65][66][67] including Overhauser MRI (OMRI) modality, which is also called as proton electron double resonance imaging (PEDRI) or dynamic nuclear polarization (DNP) [68][69][70]. Those EPR based methods, however, currently are limited only for experimental animals, such as mice or rats.…”

Understanding the g-tensors of perchlorotriphenylmethyl and Finland-type trityl radicals

“…Stable triphenylmethyl (trityl) radicals have been used in a wide variety of fields including magnetic materials, 1-3 molecular switches, 4,5 donor-acceptor systems, [6][7][8] molecular junctions, 9,10 dynamic nuclear polarization (DNP), [11][12][13][14][15][16][17] EPR distance measurements, [18][19][20][21][22][23][24][25][26][27] and in situ and in vivo applications 28 such as MRI [29][30][31] and EPR [32][33][34][35][36][37] imaging. Perchlorotriphenylmethyl (PTM) 38 and tetrathiatriarylmethyl (TAM) 39 radicals are two classes of trityl radicals ( Figure 1) that have received much attention.…”