2012
DOI: 10.1111/vco.12002
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EGFRoverexpression in canine primary lung cancer: pathogenetic implications and impact on survival

Abstract: This study reports the main clinicopathological features of primary lung cancer (PLC) in 37 dogs, with special regard to the pathogenetic and prognostic role of epidermal growth factor receptor (EGFR) overexpression. For each case the following characteristics were evaluated: tumour-node-metastasis (TNM) stage, tumour histotype, histological grade, mitotic activity and immunohistochemical expression of EGFR. In samples with available normal lung tissue, the amount of background anthracosis was also measured by… Show more

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Cited by 35 publications
(31 citation statements)
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“…With regard to EGFR expression, a significant association with tumour size (P ¼ 0.001), necrosis (P ¼ 0.001), mitotic index (P ¼ 0.022), histological grade of malignancy (P ¼ 0.041) and lymph node (Shiomitsu et al, 2009), gliomas (Higgins et al, 2010), lung tumours (Sabattini et al, 2012) and osteosarcomas (Selvarajah et al, 2012) and is associated with malignancy. However, further studies are necessary, with long-term followup, in order to clarify this subject.…”
Section: Discussionmentioning
confidence: 96%
“…With regard to EGFR expression, a significant association with tumour size (P ¼ 0.001), necrosis (P ¼ 0.001), mitotic index (P ¼ 0.022), histological grade of malignancy (P ¼ 0.041) and lymph node (Shiomitsu et al, 2009), gliomas (Higgins et al, 2010), lung tumours (Sabattini et al, 2012) and osteosarcomas (Selvarajah et al, 2012) and is associated with malignancy. However, further studies are necessary, with long-term followup, in order to clarify this subject.…”
Section: Discussionmentioning
confidence: 96%
“…19,33,36 The EGFR pathway is also reportedly overexpressed in approximately 75% of canine lung tumors, many of which also express TTF-1. 26,29 A combination of immunohistochemical markers, including TTF-1, napsin A, and SP-A, is used to diagnose human pulmonary tumors. 12,18,[20][21][22]30,34,42 Expressed in normal lung and thyroid, TTF-1 is a nuclear transcription factor detected in more than 70% of human lung tumors.…”
mentioning
confidence: 99%
“…Its ligands, EGF and transforming growth factor-α, bind to the ectodomain of EGFR to elicit biological effects through the RAS/RAF/mitogen-activated protein kinase kinase 1/extracellular signal-related kinase pathway, the phosphoinositide 3-kinase/AKT pathway, the phospholipase-Cγ/protein kinase C pathway, the SRC/signal transducer and activator of transcription pathway and the corresponding crosstalk, leading to the regulation of cellular proliferation, survival, apoptosis, invasion and metastasis (11,12). The overexpression of EGFR usually indicates rapid progress, resistance to chemoradiotherapy and a poor prognosis for patients with lung cancer (13,14). Various small-molecule tyrosine kinase inhibitors (TKIs) and anti-EGFR antibodies targeting EGFR have been developed over the previous 30 years.…”
Section: Introductionmentioning
confidence: 99%