EGFR overexpression and macrophage infiltration correlate with poorer prognosis in HPV‐negative oropharyngeal cancer via STAT6 signaling
Huai‐Pao Lee,
Chia‐Jung Li,
Ching‐Chih Lee
Abstract:BackgroundThe prevalence of HPV‐negative oropharyngeal cancer (OPC) is higher in Asian countries. Patients with HPV‐negative OPC suffer poor outcomes. Multi‐omics analysis could provide researchers and clinicians with more treatment targets for this high‐risk group. We aimed to explore the prognostic significance of EGFR overexpression and macrophage infiltration in OPC, especially HPV‐negative OPC in this study.MethodsEGFR alternation was evaluated with TCGA, PanCancer Atlas through cBioProtal. EGFR mRNA expr… Show more
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