CYP1A1 immunohistochemistry is highly specific for angiofibroma of soft tissue among morphological mimics
Anna H Bauer,
Christopher D M Fletcher,
Jason L Hornick
et al.
Abstract:AimsAngiofibroma of soft tissue (AFST) is a benign, morphologically distinctive tumour type that harbours recurrent AHRR::NCOA2 fusions in 60–70% of cases and shows a non‐specific immunophenotype, expressing EMA in roughly half of cases. The AHRR::NCOA2 fusion results in increased expression of cytochrome P450 1A1 (CYP1A1); a recent study demonstrated CYP1A1 immunohistochemistry (IHC) to be moderately sensitive and highly specific for AFST.Methods and resultsIn this study, we sought to validate these findings … Show more
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