Abstract:The antiviral response is a tightly regulated process that follows specific patterns of timing and duration. The type I interferon‐induced antiviral pathway is driven by JAK‐STAT signalling. This is characterized by the dimerization of the receptor upon ligand binding, inducing cytoplasmic protein–protein interactions between phosphorylated STAT1 and STAT2, dimerization and nuclear translocation, which leads to the formation of a trimeric transcriptional competent complex, followed by INF‐inducible gene expres… Show more
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