<scp>COVID</scp>‐19 vaccine hesitancy in renal transplant recipients

Jukić, Nikolina Bašić; Furić-Čunko, Vesna; Jelaković, Bojan

doi:10.1111/1744-9987.13750

Cited by 6 publications

(8 citation statements)

References 4 publications

(3 reference statements)

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“…Compared to the previous outbreak (1), in which 11 out of 37 hospitalized patients with the same virus variant died (29.7%), in this cohort, only nine patients required hospitalization, but only two died (2.7%). We acknowledge that the small sample size does not allow any definitive conclusion, but the mortality rate showed a progressive decline across infection waves, reaching values lower than what was reported in the general population [ 10 ]. We therefore believe that, as well as being linked to improved standard treatments, this is a vaccine-related benefit.…”

Section: Discussionmentioning

confidence: 87%

How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience

et al. 2022

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Kidney transplant recipients are a vulnerable population at risk of a life-threatening COVID-19 infection with an incidence of death four-times higher than in the general population. The availability of mRNA COVID-19 vaccines has dramatically changed the fate of this infection also within this fragile population. Transplanted patients have an impaired immunological response also to mRNA vaccines. In March 2021, however, we started a vaccination campaign. These preliminary results show that both the incidence of death and of hospitalization dropped from 13% to 2.4% and from 45% to 12.5% compared to the previous outbreaks reported by our group. In univariate analysis, two variables were associated with an increased risk of hospitalization: older age and dyspnea (p = 0.023, p < 0.0001, respectively). In multivariate analysis, dyspnea (p < 0.0001) and mycophenolate therapy (p = 0.003) were independently associated with the risk of hospitalization. The association was even stronger when the two variables were combined (p < 0.0001). Vaccinations did not reduce the incidence of COVID-19 infections among our transplanted patients, but provided certain protection that was associated with a significantly better outcome for this infection.

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Section: Discussionmentioning

confidence: 87%

How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience

et al. 2022

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“…4 Department of Anesthesiology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi, China. 5 Department of Anesthesiology, Guilin People's Hospital, Guilin 541002, China.…”

Section: Abbreviationsmentioning

confidence: 99%

“…COVID-19 has a higher likelihood of inducing moderate to severe pneumonia in individuals who have received kidney transplants [ 1 , 12 ]. Despite the significant therapeutic effects of COVID-19 vaccines in the general population, vaccinated KTRs still face the risk of breakthrough infection, with a mortality risk 8.1 times higher than that in the general population [ 5 , 11 , 23 ]. Hence, exploring the single-cell immune profile of KTRs with COVID-19-induced ARDS, particularly in regards to the impact of virus infection and immunosuppression, is crucial for effectively managing the disease and promoting recovery in patients.…”

Section: Introductionmentioning

confidence: 99%

Immune characteristics of kidney transplant recipients with acute respiratory distress syndrome induced by COVID-19 at single-cell resolution

Lu,

Chen,

Zhou

et al. 2024

Respir Res

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Background COVID-19-induced acute respiratory distress syndrome (ARDS) can result in tissue damage and multiple organ dysfunction, especially in kidney transplant recipients (KTRs) receiving immunosuppressive drugs. Presently, single-cell research on COVID-19-induced ARDS is considerably advanced, yet knowledge about ARDS in KTRs is still constrained. Methods Single-cell RNA sequencing (scRNA-seq) analysis was performed to construct a comprehensive single-cell immune landscape of the peripheral blood mononuclear cells (PBMCs) of eight patients with COVID-19-induced ARDS, five KTRs with COVID-19-induced ARDS, and five healthy individuals. Subsequently, we conducted a comprehensive bioinformatics analysis, including cell clustering, enrichment analysis, trajectory analysis, gene regulatory network analysis, and cell–cell interaction analysis, to investigate the heterogeneity of the immune microenvironment in KTRs with ARDS. Result Our study revealed that KTRs exhibit significant heterogeneity with COVID-19-induced ARDS compared with those of other individuals, with significant reductions in T cells, as well as an abnormal proliferation of B cells and monocytes. In the context of dual influences from immunosuppression and viral infection, KTRs exhibited more specific plasma cells, along with significant enrichment of dysfunctional GZMB and XAF1 double-positive effector T cells and IFI27-positive monocytes. Additionally, robust communication existed among T cells and monocytes in cytokine signaling. These effects impede the process of immune reconstitution in KTR patients. Conclusion Our findings suggest that KTRs with COVID-19-induced ARDS show elevated antibody levels, impaired T cell differentiation, and dysregulation of innate immunity. In summary, this study provides a theoretical foundation for a comprehensive understanding of COVID-19-induced ARDS in KTRs.

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“…A survey of renal transplant recipients in Croatia found that 3.9% of patients had refused COVID-19 vaccination, once again most often citing fear of side effects. A small number of individuals responded that they did not believe in COVID-19, did not believe they could be infected or did not fear the consequences of the disease [38]. A survey of transplant recipients in China found that 11.6% would refuse COVID-19 vaccination.…”

Section: Volitional Stopsmentioning

confidence: 99%

Approaches to pretransplant vaccination

Kates¹

2022

Current Opinion in Organ Transplantation

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Purpose of reviewThe aim of this study was to summarize new data and perspectives in pretransplant vaccination, with a particular focus on COVID-19 vaccination and vaccination requirements. Recent findingsPretransplant vaccination produces superior markers of immunity and is expected to have greater clinical benefit, compared with posttransplant vaccination. As such, efforts are underway to identify and characterize barriers to pretransplant vaccination, with a particular focus on COVID-19 vaccine hesitancy. Unfortunately, vaccine hesitancy is common in transplant patients, often motivated by individual side effect and safety concerns. COVID-19 vaccination requirements have been implemented in some centres, informed by ethical principles, including beneficence, utility and justice.

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COVID‐19 vaccine hesitancy in renal transplant recipients

Cited by 6 publications

References 4 publications

How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience

How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience

Immune characteristics of kidney transplant recipients with acute respiratory distress syndrome induced by COVID-19 at single-cell resolution

Approaches to pretransplant vaccination

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