<scp>COVID</scp>‐19: Impact of obesity and diabetes on disease severity

Al-Sabah, Salman; Al‐Haddad, Mohannad; Youha, Sarah Al; Jamal, Mohammad H.; Almazeedi, Sulaiman

doi:10.1111/cob.12414

Cited by 61 publications

(59 citation statements)

References 20 publications

(13 reference statements)

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“…The authors also found that the number of patients needing ICU admission did not differ from that with CV disease (20.4%) although it was higher than that with chronic lung disease (14.3%) or at an immuno-compromised status (15.5%). A report in Kuwait states that individuals with DM and obesity are more prone to ICU admission as the COVID-19 pandemic continues (46).…”

Section: Morbidity Of Sars-cov-2 Infection In Diabetic Patientsmentioning

confidence: 99%

Factors Behind the Higher COVID-19 Risk in Diabetes: A Critical Review

Beshbishy

Oti

Hussein

et al. 2021

Front. Public Health

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Diabetes mellitus (DM) and coronavirus disease 2019 (COVID-19) are public health issues worldwide, and their comorbidities trigger the progress to severe disease and even death in such patients. Globally, DM has affected an estimated 9.3% adults, and as of April 18, 2021, the World Health Organization (WHO) has confirmed 141,727,940 COVID-19 confirmed cases. The virus is spread via droplets, aerosols, and direct touch with others. Numerous predictive factors have been linked to COVID-19 severity, including impaired immune response and increased inflammatory response, among others. Angiotensin receptor blockers and angiotensin converting enzyme 2 have also been identified as playing a boosting role in both susceptibility and severity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Specifically, in DM patients, both their control and management during this pandemic is herculean as the restriction periods have markedly hampered the maintenance of means to control glycemia, hypertension, and neuroendocrine and kidney diseases. In addition, as a result of the underlyin cardio-metabolic and immunological disorders, DM patients are at a higher risk of developing the severe form of COVID-19 despite other comorbidities, such as hypertension, also potentially boosting the development of higher COVID-19 severity. However, even in non-DM patients, SARS-CoV-2 may also cause transient hyperglycemia through induction of insulin resistance and/or pancreatic β-cell injury. Therefore, a strict glucose monitoring of DM patients with COVID-19 is mandatory to prevent life-threatening complications.

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Section: Morbidity Of Sars-cov-2 Infection In Diabetic Patientsmentioning

confidence: 99%

Factors Behind the Higher COVID-19 Risk in Diabetes: A Critical Review

Beshbishy

Oti

Hussein

et al. 2021

Front. Public Health

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“…The association between obesity and the severity of COVID-19 has been reported in several studies. However, it is important to demonstrate that the association was also observed in Japanese patients who are generally less obese than patients in Europe and the United States [14,15]. As regards underlying diseases, previous reports showed that comorbidities such as hypertension, diabetes mellitus, and cardiovascular disease correlate with COVID-19 mortality.…”

Section: Discussionmentioning

confidence: 93%

Clinical characteristics of Japanese patients with moderate to severe COVID-19

Otoshi

Hagiwara

Kitayama

et al. 2021

Journal of Infection and Chemotherapy

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Introduction: Although several reports on the risk factors for severe disease of COVID-19 already exist, reports on effective early indicators are still limited, especially from Japan. This study was conducted to clarify the patient's characteristics whose disease progressed to severe status. Methods: The medical records of all consecutive 300 Japanese patients hospitalized at our institution between February and November 2020 were retrospectively reviewed. The clinical characteristics were evaluated to compare between mild (no oxygen needed), moderate (oxygen needs of 1e4 L/min), and severe diseases (oxygen needs of 5 L/min or more). Results: The median age was 68 years old, with 123 (41.0%) males and 177 (59.0%) females. Of these, 199 patients (66.3%), 55 patients (18.3%), 46 patients (15.3%) patients were in the mild disease, moderate disease, severe disease groups, respectively. Patients with severe disease were more likely to be older, have more comorbidities, and tended to have higher body mass index. In laboratory data, lymphocyte count, levels of C-reactive protein (CRP), LDH, and AST on admission were significantly associated with the severity. In multivariate analysis, age and CRP were the independent risk factors for severe disease (OR ¼ 1.050, 1.130, respectively). The optimal cut-off value for age was 74 years old and that for CRP was 3.15 mg/dL. Conclusions: Age and CRP were independently associated with disease severity of COVID-19 in multivariate analysis. Additionally, the numbers of underlying disease, lymphocyte count, and inflammatory markers such as LDH and D-dimer may also be related to disease severity.

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“…(10,11) In particular people with diabetes and obesity are reportedly at greater risk for severe COVID-19 symptoms. (17,(30)(31)(32)(33)(34) Therefore, in the COVID-19 era, the prevention and treatment of diabetes and other lifestyle diseases assumes even greater importance. Conversely, during the COVID-19 era, the stay-at-home policy has led to significant changes in people's life-styles.…”

Section: Discussionmentioning

confidence: 99%

Status of online diet management program users in Japan during the 2020 Coronavirus disease 2019 pandemic

Hamaguchi

Nojiri

Okamura

et al. 2021

J. Clin. Biochem. Nutr.

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The spread of coronavirus disease 2019 (COVID-19) has led to drastic changes in people's lifestyles, including teleworking and restrictions on socializing. In the context of observing social distancing for preventing infection, the need to maintain fitness and health has attracted particular attention. We aimed to determine the relationship between the increase in the number of active users of online diet management applications and COVID-19 infection rates in Japan. A total of 1.5 million rows of log data was analyzed. The active number of users of online diet management applications increased with increase in the number of COVID-19 infections. The active user number in Kanagawa Prefecture, where the first cases of COVID-19 were reported in Japan, was particularly high. Moreover, there was a significant increase in the user number in prefectures under a state of emergency when compared to that in prefectures not under a state of emergency. The social anxiety caused by COVID-19 is expected to increase the demand for online health management applications further. The use of such programs can aid in achieving social distancing while enabling users to maintain healthy lifestyles.

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COVID‐19: Impact of obesity and diabetes on disease severity

Cited by 61 publications

References 20 publications

Factors Behind the Higher COVID-19 Risk in Diabetes: A Critical Review

Factors Behind the Higher COVID-19 Risk in Diabetes: A Critical Review

Clinical characteristics of Japanese patients with moderate to severe COVID-19

Status of online diet management program users in Japan during the 2020 Coronavirus disease 2019 pandemic

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