<scp>COMPRES</scp>: a prospective postmarketing evaluation of the compression anastomosis ring <scp>CAR</scp> 27<sup>™</sup>/ColonRing<sup>™</sup>

D’Hoore, André; Albert, Matthew; Cohen, Stephen M.; Herbst, F.; Matter, Ibrahim; Speeten, Kurt Van der; Domı́nguez, J.; Rutten, H.J.T.; Muldoon, Joseph P.; Bardakcioglu, Ovunc; Senagore, Anthony J.; Ruppert, R.; Mills, Steven; Stamos, Michael J.; Påhlman, Lars; Choman, Eran; Wexner, Steven D.

doi:10.1111/codi.12884

Cited by 13 publications

(12 citation statements)

References 21 publications

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“…A retrospective multicentric study including 1’180 patients described an AL rate of 3.22% using the ColonRing device[52]. Further, a prospective postmarketing evaluation of the ColonRing described an AL rate of 5.3% among 266 patients, but a septic anastomotic complication rate of 8.3%, which could reflect the true AL rate[53]. A recent systematic review and meta-analysis including 10 RCT (1’969 patients) found no difference in terms of AL between patients with handsewn or stapled anastomosis (977 patients) and those with compression anastomoses (992 patients)[54].…”

Section: Operative Measures To Prevent Almentioning

confidence: 99%

Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges

Meyer¹,

Naiken²,

Christou³

et al. 2019

WJG

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Anastomotic leak (AL) constitutes a significant issue in colorectal surgery, and its incidence has remained stable over the last years. The use of intra-abdominal drain or the use of mechanical bowel preparation alone have been proven to be useless in preventing AL and should be abandoned. The role or oral antibiotics preparation regimens should be clarified and compared to other routes of administration, such as the intravenous route or enema. In parallel, preoperative antibiotherapy should aim at targeting collagenase-inducing pathogens, as identified by the microbiome analysis. AL can be further reduced by fluorescence angiography, which leads to significant intraoperative changes in surgical strategies. Implementation of fluorescence angiography should be encouraged. Progress made in AL comprehension and prevention might probably allow reducing the rate of diverting stoma and conduct to a revision of its indications.

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Section: Operative Measures To Prevent Almentioning

confidence: 99%

Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges

Meyer¹,

Naiken²,

Christou³

et al. 2019

WJG

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“…Most recently, the nickel‐titanium (nitinol; NiTi) ColonRing device has been introduced with compression rings that possess shape memory and elasticity to provide more uniform compression of the tissue. Despite a large multicentre, multinational study involving 1180 patients , and a prospective multicentre study reporting leakage rates of just over 3% , the device has not gained widespread application.…”

Section: Anastomotic Constructionmentioning

confidence: 99%

A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery

et al. 2017

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The reduction of the incidence, detection and treatment of anastomotic leakage (AL) continues to challenge the colorectal surgical community. AL is not consistently defined and reported in clinical studies, its occurrence is variably reported and its impact on longterm morbidity and health-care resources has received relatively little attention. Controversy continues regarding the best strategies to reduce the risk. Diagnostic tests lack sensitivity and specificity, resulting in delayed diagnosis and increased morbidity. Intra-operative fluorescence angiography has recently been introduced as a means of real-time assessment of anastomotic perfusion and preliminary evidence suggests that it may reduce the rate of AL. In addition, concepts are emerging about the role of the rectal mucosal microbiome in AL and the possible role of new prophylactic therapies. In January 2016 a meeting of expert colorectal surgeons and pathologists was held in London, UK, to identify the ongoing controversies surrounding AL in colorectal surgery. The outcome of the meeting is presented in the form of research challenges that need to be addressed.

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“…In the immediate post-operative period, additional medical and surgical procedures prolong hospitalization and increase expense. One recent study revealed a six-fold increase in 30-day mortality following anastomotic leak 49 incidence of leak following compression anastomosis 50,51 . Other novel approaches have been internal bypass and anastomotic sealants 52,53 .…”

Section: Attempts To Reduce Anastomotic Leaks Sd Wexnermentioning

confidence: 99%

The Future of Rectal Cancer Surgery: A Narrative Review of an International Symposium

et al. 2018

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Surgery remains the mainstay of curative treatment for primary rectal cancer. For mid and low rectal tumors, optimal oncologic surgery requires total mesorectal excision (TME) to ensure the tumor and locoregional lymph nodes are removed. Adequacy of surgery is directly linked to survival outcomes and, in particular, local recurrence. From a technical perspective, the more distal the tumor, the more challenging the surgery and consequently, the risk for oncologically incomplete surgery is higher. TME can be performed by an open, laparoscopic, robotic or transanal approach. There is a lack of consensus on the "gold standard" approach with each of these options offering specific advantages. The International Symposium on the Future of Rectal Cancer Surgery was convened to discuss the current challenges and future pathways of the 4 approaches for TME. This article reviews the findings and discussion from an expert, international panel.

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COMPRES: a prospective postmarketing evaluation of the compression anastomosis ring CAR 27^™/ColonRing^™

Abstract: Nitinol compression anastomosis is safe, effective and easy to use and may offer an advantage for low colorectal anastomosis. A prospective randomized trial comparing ColonRing(™) with conventional stapling is needed.

Cited by 13 publications

References 21 publications

Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges

Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges

A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery

The Future of Rectal Cancer Surgery: A Narrative Review of an International Symposium

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COMPRES: a prospective postmarketing evaluation of the compression anastomosis ring CAR 27™/ColonRing™

Abstract: Nitinol compression anastomosis is safe, effective and easy to use and may offer an advantage for low colorectal anastomosis. A prospective randomized trial comparing ColonRing(™) with conventional stapling is needed.

Cited by 13 publications

References 21 publications

Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges

Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges

A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery

The Future of Rectal Cancer Surgery: A Narrative Review of an International Symposium

Contact Info

Product

Resources

About

COMPRES: a prospective postmarketing evaluation of the compression anastomosis ring CAR 27^™/ColonRing^™