<scp>CLIF</scp>‐<scp>SOFA</scp> scoring system accurately predicts short‐term mortality in acutely decompensated patients with alcoholic cirrhosis: a retrospective analysis

Lee, Minjong; Lee, Jeong Hoon; Oh, Sohee; Jang, Yoonhyuk; Lee, Wonik; Lee, Hyung Joo; Yoo, Jeong‐Ju; Choi, Won‐Mook; Cho, Young Youn; Cho, Yuri; Lee, Dong Hoon; Lee, Yun Bin; Yu, Su Jong; Yi, Nam Joon; Lee, Kwang Woong; Kim, Yoon Jun; Yoon, Jung Hwan; Suh, Kyung Suk; Lee, Hyo Suk

doi:10.1111/liv.12683

Cited by 62 publications

(60 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is a single‐center study, limiting generalizability. This is highlighted by the relatively low predictive value of validated prognostic scores such as MELD, MELD‐Na, and CLIF‐C ACLF, compared with other populations of patients with liver disease . Results likely best apply to hospitalized patients with decompensated cirrhosis and AKI, and further study should be performed across a broader spectrum of patients with advanced liver disease.…”

Section: Discussionmentioning

confidence: 99%

Serum Angiopoietin‐2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis

et al. 2019

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Serum Angiopoietin‐2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…[14] Another study showed that the CLIF-C ACLFs may be more useful for predicting 28-day and 90-day mortality in ACLF cases than CTP, MELD, and MELD-sodium scores in alcohol-related ACLF. [15] Our results in CHB patient with ACLF were similar to that in those previous studies, but the best performance was CLIF-OFs, not CLIF-SOFA or CLIF-C ACLFs.…”

Section: Discussionmentioning

confidence: 99%

Validation of prognostic scores to predict short-term mortality in patients with HBV-related acute-on-chronic liver failure

Huang

et al. 2017

Medicine

View full text Add to dashboard Cite

Acute-on-chronic liver failure (ACLF) in chronic hepatitis B (CHB) patients has a high short-term mortality. Identification of effective models to predict the short-term mortality may enable early intervention and improve patients’ prognosis. We aim to assess the performance of the CLIF Consortium Organ Failure score (CLIF-C OFs), CLIF sequential organ failure assessment score (CLIF-SOFAs), CLIF Consortium ACLF score (CLIF-C ACLFs), ACLF grade, and model for end-stage liver disease score (MELDs) in predicting the short-term mortality in CHB patients with ACLF.Among the 155 consecutive adult patients with liver failure as a discharge diagnosis were screened, and all the patients were treated at the Department of Infectious Diseases, Huashan Hospital, Fudan University (Shanghai, China) from January 2010 to February 2016. The diagnosis of ACLF was based on the criteria formalized by the ACLF consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Diagnostic accuracy for predicting short-term (28-day) mortality was calculated for CLIF-C OFs, CLIF-SOFAs, CLIF-C ACLFs, ACLF grade, and MELDs in all patients.One hundred fifty-five consecutive adult liver failure patients were screened and 85 patients including 73 males and 12 females were enrolled. Overall, the 28-day transplant-free mortality was 32% in all patients, and 100% in those with severe early course (ACLF-3). The area under the receiver operating characteristic curve (AUROC) of CLIF-C OFs (AUROC: 0.906, P = .0306, compared with MELDs) was higher than those of CLIF-SOFAs (AUROC: 0.876), CLIF-C ACLFs (AUROC: 0.858), ACLF grade (AUROC: 0.857), and MELDs (AUROC: 0.838) for predicting short-term mortality. The cut-point for baseline CLIF-C OFs in predicting death was 8.5, with 67% sensitivity, 90% specificity, and AUROC of 0.906 (95% CI: 0.8450–0.9679).The results indicate that short-term mortality is high in patients with ACLF and CLIF Consortium Organ Failure score is superior to MELD, CLIF SOFA, and CLIF-C ACLF in predicting its short-term mortality.

show abstract

“…9–12, 42 However, a careful look at trends in eGFR may offer insight into which patients might benefit from TIPS, as kidney function is closely tied to mortality and is a key component of prognostic scores in cirrhosis. 36, 43–47 Placement of TIPS has been associated with improvement in kidney function in small studies. 17, 26, 27, 29, 30, 32, 48, 49 We were able to confirm and elaborate on this phenomenon using multivariable analysis.…”

Section: Discussionmentioning

confidence: 99%

Changes in Kidney Function After Transjugular Intrahepatic Portosystemic Shunts Versus Large-Volume Paracentesis in Cirrhosis: A Matched Cohort Analysis

Allegretti

Ortiz

Cui

et al. 2016

American Journal of Kidney Diseases

View full text Add to dashboard Cite

Background Patients with cirrhosis and refractory ascites have physiologic and hormonal dysregulation that contributes to decreased kidney function. Placement of a transjugular intrahepatic portosystemic shunt (TIPS) can reverse these changes and potentially improve kidney function. We sought to evaluate change in estimated glomerular filtration rate (eGFR) following TIPS. Study Design Retrospective, matched cohort analysis. Settings & Participants Patients who underwent first-time TIPS placement for refractory ascites in 1995–2014. Frequency matching was used to generate a comparator group of patients with cirrhosis and ascites treated with serial large-volume paracentesis (LVP) in a 1:1 fashion. Predictor TIPS placement compared to serial LVP. Outcome Change in eGFR over 90 days’ follow-up. Measurements Multivariable regression stratified by baseline eGFR <60 vs. ≥60 mL/min/1.73 m2; analysis of effect modification between TIPS placement and baseline eGFR. Results 276 subjects (TIPS, n=138; serial LVP, n=138) were analyzed. After 90 days, eGFR increased significantly after TIPS placement in subjects with baseline eGFR <60 mL/min/1.73 m2 compared to treatment with serial LVP (21 [95% CI, 13–29] mL/min/1.73 m2; p <0.001) and was no different in those with eGFR ≥60 mL/min/1.73 m2 (1 [−9 to 12] mL/min/1.73 m2; p = 0.8). There was significant effect modification between TIPS status and baseline eGFR (p = 0.001) in a model that included all subjects. Limitations Outcomes restricted by clinically recorded data; clinically important differences may still exist between TIPS and LVP cohorts despite good statistical matching. Conclusions TIPS placement was associated with a significant improvement in kidney function. This was most prominent in subjects with baseline eGFR <60 mL/min/1.73 m2. Prospective studies of TIPS in populations with eGFR <60 mL/min/1.73 m2 are needed to evaluate these findings.

show abstract

CLIF‐SOFA scoring system accurately predicts short‐term mortality in acutely decompensated patients with alcoholic cirrhosis: a retrospective analysis

Abstract: CLIF-SOFA enables more accurate prediction of short-term mortality in patients with acutely decompensated alcoholic cirrhosis than other available scoring systems and is useful in predicting both 12-week mortality and the need for mechanical support after liver transplantation.

Cited by 62 publications

References 21 publications

Serum Angiopoietin‐2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis

Serum Angiopoietin‐2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis

Validation of prognostic scores to predict short-term mortality in patients with HBV-related acute-on-chronic liver failure

Changes in Kidney Function After Transjugular Intrahepatic Portosystemic Shunts Versus Large-Volume Paracentesis in Cirrhosis: A Matched Cohort Analysis

Contact Info

Product

Resources

About