2022
DOI: 10.1002/ijc.34059
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CD8 agonism functionally activates memory T cells and enhances antitumor immunity

Abstract: Memory CD8+ T cells mature after antigen clearance and ultimately express CD8 protein at levels higher than those detected in effector CD8+ T cells. However, it is not clear whether engagement of CD8 in the absence of antigenic stimulation will result in the functional activation of T cells. Here, we found that CD8 antibody‐mediated activation of memory CD8+ T cells triggered T cell receptor (TCR) downstream signaling, enhanced T cell‐mediated cytotoxicity and promoted effector cytokine production in a glucose… Show more

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Cited by 4 publications
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“…However, this hypothesis must be tested in future studies, and additional data regarding mitochondrial morphology and the expression of other mitochondria-related genes would further add to our understanding of this phenomenon. It is unclear from our current data whether CD8 expression directly regulates mitochondrial activity in CD8 T cells; however a recent study reported that CD8 agonism boosted CD8 T cell metabolism and anti-tumor responses ( Madi et al, 2022 ). This suggests there may be a direct link between CD8 levels on T cells and their metabolic activity, and that CD8 may be a viable therapeutic target to boost anti-tumor T cell immunity.…”
Section: Discussionmentioning
confidence: 69%
“…However, this hypothesis must be tested in future studies, and additional data regarding mitochondrial morphology and the expression of other mitochondria-related genes would further add to our understanding of this phenomenon. It is unclear from our current data whether CD8 expression directly regulates mitochondrial activity in CD8 T cells; however a recent study reported that CD8 agonism boosted CD8 T cell metabolism and anti-tumor responses ( Madi et al, 2022 ). This suggests there may be a direct link between CD8 levels on T cells and their metabolic activity, and that CD8 may be a viable therapeutic target to boost anti-tumor T cell immunity.…”
Section: Discussionmentioning
confidence: 69%