<scp>CD</scp>24<sup>hi</sup><scp>CD</scp>27<sup>+</sup> B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide

Vlugt, Luciën E. P. M. van der; Mlejnek, E.; Ozir‐Fazalalikhan, Arifa; Janssen, Rob; Dijksman, T. R.; Labuda, Lucja A.; Schot, Robert; Guigas, Bruno; Möller, Gertrude M.; Hiemstra, Pieter S.; Yazdanbakhsh, Maria; Smits, Hermelijn H.

doi:10.1111/cea.12238

Cited by 85 publications

(72 citation statements)

References 47 publications

(68 reference statements)

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“…Hi Breg frequencies have been observed in asthmatic patients not taking medication [10]. In our study, there were no differences in Breg subsets on comparing asthmatic and nonasthmatic patients, but our patients were all taking medication at recruitment.…”

Section: Cd38contrasting

confidence: 56%

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Regulatory T and B cells in asthmatic women: variations from pregnancy to postpartum

Martins¹,

Lima²,

Nunes³

et al. 2017

J Investig Allergol Clin Immunol

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Section: Cd38contrasting

confidence: 56%

“…Hi CD27 + Bregs have been observed in patients with asthma and/or allergic rhinitis [10,35], although increased CD24…”

Section: Decreased Frequencies Of Cd24mentioning

confidence: 99%

Regulatory T and B cells in asthmatic women: variations from pregnancy to postpartum

Martins¹,

Lima²,

Nunes³

et al. 2017

J Investig Allergol Clin Immunol

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“…Thus, a relation between high proportions of neonatal CD5 + B cells and sensitization in children with allergic disease who are .3 y old may not be ruled out. Indeed, it was recently shown that sensitized adult subjects with allergic asthma had significantly higher proportions of circulating immature transitional B cells defined as CD24 hi CD38 hi compared with healthy individuals (32). It should be noted, however, that the absolute numbers of CD24 hi CD38 hi B cells did not differ between these two groups (32).…”

Section: Discussionmentioning

confidence: 96%

High Proportion of CD5+ B Cells in Infants Predicts Development of Allergic Disease

Lundell

Johansen

Adlerberth

et al. 2014

The Journal of Immunology

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Delayed maturation of the immune system has been proposed to be a risk factor for development of allergy, but B cell maturation in relation to allergic disease has not been examined. B cells lose CD5 and acquire CD27 during maturation from immature via mature/naive to Ig-secreting cells and memory cells. We sought to investigate B cell maturation in relation to development of allergic disease and sensitization in the FARMFLORA birth cohort including 65 Swedish children. Total B cell numbers, proportions of CD5+ and CD27+ B cells, and levels of IgM, IgG, IgA, and IgE were measured in blood on repeated occasions from birth to 36 mo of age, and related to allergic disease and sensitization at 18 and 36 mo of age with multivariate discriminant analysis. We also compared the expression of CD24 and CD38 within CD5+ and CD5neg B cells in children and in adults. We found that infants with a high proportion of CD5+ B cells at birth and at 1 mo of age had an increased risk for having allergic disease at 18 and 36 mo of life. Further, the proportions of CD5+ B cells at 1 mo of age were inversely correlated with total IgG levels at 18 and 36 mo of age. The majority of the CD5+ B cells were of a CD24hi/+CD38hi/+ immature/naive phenotype at birth (97%), 7 y of age (95%), and in adults (86%). These results suggest that development of allergic disease is preceded by an immaturity in neonatal B cell phenotype.

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“…In a recent study, B cells were attributed an important role in T H 2 responses and airway inflammation [9]. Impaired regulatory activity has also been reported for regulatory B cells (Bregs) in allergic asthma [10], and these cells are closely related to Tregs [11].…”

Section: Introductionmentioning

confidence: 98%

Regulatory T and B Cells in Asthmatic Women: Variations From Pregnancy to Postpartum

Martins¹,

Lima²,

Nunes³

et al. 2017

J Investig Allergol Clin Immunol

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Background and Objectives: Allergic asthma and rhinitis are common in pregnancy. The immune mechanisms underlying the effects of asthma on pregnancy and vice versa are not completely understood. The aim of this study was to investigate changes in regulatory T and B cells in asthmatic women from late pregnancy to postpartum. Methods: Four groups of women were enrolled for this study: asthmatic (n=23) and healthy (n=43) third trimester-pregnant women and asthmatic (n=33) and healthy (n=35) nonpregnant women. Pregnant women were also evaluated postpartum (>6 weeks after delivery). Blood samples were taken from each woman and flow cytometry was used to characterize circulating regulatory T cells (Tregs) and regulatory B cells (Bregs). Foxp3 expression was assessed in CD4

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CD24^hiCD27⁺ B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide

Abstract: Taken together, these data indicate that CD24(hi)CD27(+) B cells from allergic asthma patients produce less IL-10 in response to LPS leading to a weaker IL-10 induction in T cells in response to DerP1, which may play a role in allergic asthma.

Cited by 85 publications

References 47 publications

Regulatory T and B cells in asthmatic women: variations from pregnancy to postpartum

Regulatory T and B cells in asthmatic women: variations from pregnancy to postpartum

High Proportion of CD5+ B Cells in Infants Predicts Development of Allergic Disease

Regulatory T and B Cells in Asthmatic Women: Variations From Pregnancy to Postpartum

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CD24hiCD27+ B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide

Abstract: Taken together, these data indicate that CD24(hi)CD27(+) B cells from allergic asthma patients produce less IL-10 in response to LPS leading to a weaker IL-10 induction in T cells in response to DerP1, which may play a role in allergic asthma.

Cited by 85 publications

References 47 publications

Regulatory T and B cells in asthmatic women: variations from pregnancy to postpartum

Regulatory T and B cells in asthmatic women: variations from pregnancy to postpartum

High Proportion of CD5+ B Cells in Infants Predicts Development of Allergic Disease

Regulatory T and B Cells in Asthmatic Women: Variations From Pregnancy to Postpartum

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CD24^hiCD27⁺ B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide