<scp>C</scp>‐fibre sensory nerves – not so silent as we think?

Panicker, Jalesh N.; Seth, Jai

doi:10.1111/bju.12271

Cited by 6 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spinal shock is gradually replaced by NDO, as a result of the neuroplastic rearrangement of micturition reflexes at the lumbosacral spinal cord [ 77 ]. These rearrangements are dependent on C-fibers [ 11 , 25 , 78 ], which undergo axonal sprouting in the bladder and lumbosacral cord [ 26 , 27 , 79 ] and lower their threshold [ 80 ], resulting in NDO [ 11 , 81 ]. Neuroplastic changes also likely contribute to DSD, which is frequently associated with NDO and leads to increased intravesical pressures and high volumes of residual urine, associated with a high risk of urinary infections and kidney deterioration [ 82 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular Mechanism Operating in Animal Models of Neurogenic Detrusor Overactivity: A Systematic Review Focusing on Bladder Dysfunction of Neurogenic Origin

Ferreira

Nascimento

Cruz

2023

IJMS

View full text Add to dashboard Cite

Neurogenic detrusor overactivity (NDO) is a severe lower urinary tract disorder, characterized by urinary urgency, retention, and incontinence, as a result of a neurologic lesion that results in damage in neuronal pathways controlling micturition. The purpose of this review is to provide a comprehensive framework of the currently used animal models for the investigation of this disorder, focusing on the molecular mechanisms of NDO. An electronic search was performed with PubMed and Scopus for literature describing animal models of NDO used in the last 10 years. The search retrieved 648 articles, of which reviews and non-original articles were excluded. After careful selection, 51 studies were included for analysis. Spinal cord injury (SCI) was the most frequently used model to study NDO, followed by animal models of neurodegenerative disorders, meningomyelocele, and stroke. Rats were the most commonly used animal, particularly females. Most studies evaluated bladder function through urodynamic methods, with awake cystometry being particularly preferred. Several molecular mechanisms have been identified, including changes in inflammatory processes, regulation of cell survival, and neuronal receptors. In the NDO bladder, inflammatory markers, apoptosis-related factors, and ischemia- and fibrosis-related molecules were found to be upregulated. Purinergic, cholinergic, and adrenergic receptors were downregulated, as most neuronal markers. In neuronal tissue, neurotrophic factors, apoptosis-related factors, and ischemia-associated molecules are increased, as well as markers of microglial and astrocytes at lesion sites. Animal models of NDO have been crucial for understanding the pathophysiology of lower urinary tract (LUT) dysfunction. Despite the heterogeneity of animal models for NDO onset, most studies rely on traumatic SCI models rather than other NDO-driven pathologies, which may result in some issues when translating pre-clinical observations to clinical settings other than SCI.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular Mechanism Operating in Animal Models of Neurogenic Detrusor Overactivity: A Systematic Review Focusing on Bladder Dysfunction of Neurogenic Origin

Ferreira

Nascimento

Cruz

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…2 ). 7 8 Additionally, normally coordinated activity between the detrusor and urethral sphincters during voiding becomes impaired, and the detrusor and urethral sphincters contract simultaneously, termed detrusor-sphincter dyssynergia (DSD). Injury to the conus medullaris, sacral roots (cauda equina), and peripheral nerves results primarily in voiding dysfunction from poorly sustained detrusor contractions, termed detrusor underactivity .…”

Section: Neurogenic Lower Urinary Tract Dysfunctionmentioning

confidence: 99%

“…LUT, lower urinary tract; NDO, neurogenic detrusor overactivity. (Used with permission from Panicker et al 7 )…”

Section: Neurogenic Lower Urinary Tract Dysfunctionmentioning

confidence: 99%

Neurogenic Bladder: Epidemiology, Diagnosis, and Management

Panicker

2020

Semin Neurol

Self Cite

View full text Add to dashboard Cite

Lower urinary tract dysfunction is a common sequel of neurological disease resulting in symptoms that significantly impacts quality of life. The site of the neurological lesion and its nature influence the pattern of dysfunction. The risk for developing upper urinary tract damage and renal failure is considerably lower in patients with slowly progressive nontraumatic neurological disorders, compared with those with spinal cord injury or spina bifida. This acknowledged difference in morbidity is considered when developing appropriate management algorithms. The preliminary evaluation consists of history taking, and a bladder diary and may be supplemented by tests such as uroflowmetry, post-void residual measurement, renal ultrasound, (video-)urodynamics, neurophysiology, and urethrocystoscopy, depending on the clinical indications. Incomplete bladder emptying is most often managed by intermittent catheterization, and storage dysfunction is managed by antimuscarinic medications. Intra-detrusor injections of onabotulinumtoxinA have revolutionized the management of neurogenic detrusor overactivity. Neuromodulation offers promise for managing both storage and voiding dysfunction. In select patients, reconstructive urological surgery may become necessary. An individualized, patient-tailored approach is required for the management of lower urinary tract dysfunction in this special population.

show abstract

Uroneurology

Panicker

2016

Neurology

View full text Add to dashboard Cite

C‐fibre sensory nerves – not so silent as we think?

Cited by 6 publications

References 10 publications

Molecular Mechanism Operating in Animal Models of Neurogenic Detrusor Overactivity: A Systematic Review Focusing on Bladder Dysfunction of Neurogenic Origin

Molecular Mechanism Operating in Animal Models of Neurogenic Detrusor Overactivity: A Systematic Review Focusing on Bladder Dysfunction of Neurogenic Origin

Neurogenic Bladder: Epidemiology, Diagnosis, and Management

Uroneurology

Contact Info

Product

Resources

About