Abstract:C
2
‐domains are the second‐most abundant Ca
2+
‐binding modules in nature. Their most common activity is Ca
2+
‐dependent phospholipid binding, but other types of interactions have been observed for these versatile protein modules. A variety of proteins involved in membrane traffic contain multiple C
2
‐domains, which often appear as two tandem C
2
‐domains as in the case of synaptotagmins a… Show more
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