<scp>BSH</scp> Guideline: management of thrombotic and haemostatic issues in paediatric malignancy

Sibson, Keith; Biss, Tina; Furness, Caroline L; Grainger, John D.; Hough, Rachael; Macartney, Christine; Payne, Jeanette; Chalmers, Elizabeth

doi:10.1111/bjh.15112

Cited by 18 publications

(25 citation statements)

References 117 publications

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“…Increasing research evidence shows that hypercoagulable state, malnutrition, and systemic inflammatory response affect tumorigenesis, tumor progression, and metastasis ( 9 , 36 ). The prognostic value of preoperative FARI is closely linked to patients with malignant tumors ( 23 , 29 – 31 ).…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen/Albumin Ratio Index Is an Independent Prognosis Predictor of Recurrence-Free Survival in Patients After Surgical Resection of Gastrointestinal Stromal Tumors

Cao

Cui

et al. 2020

Front. Oncol.

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Background: Nutritional status, systemic inflammation, and coagulation mechanism are closely related to tumor progression. Herein, we examined the role of fibrinogen-to-albumin ratio index (FARI) in the prognosis of gastrointestinal stromal tumors (GISTs) and developed a novel nomogram predicting recurrence-free survival (RFS). Methods: We retrospectively analyzed data from 357 GIST patients admitted at the gastrointestinal surgery of the Beijing Hospital from January 2008 to January 2018 and underwent curative resection. FARI was calculated as fibrinogen level (g/L) /albumin level (g/L). The cutoff point of FARI was set using the point with the largest Youden index on the receiver operating characteristic curve with the 5-years recurrence-free survival as an endpoint. We used the Kaplan-Meier approach and multivariable Cox regression model to study the impact of FARI on recurrence-free survival. Finally, we developed a nomogram based on tumor size, location, mitotic index, and FARI to predict RFS. The nomogram was assessed by calculating concordance probabilities and testing calibration of predicted RFS with observed RFS. Concordance probabilities were also compared with the National Institute of Health (NIH) risk classification system. Results: The ROC curve revealed that the best cutoff point of the FARI was set as 0.08. The patients were classified into the FARI-high (≥0.08) and FARI-low (<0.08) groups. FARI was significantly associated with age, size of the tumor, NIH risk category, and Mitotic Index (all P < 0.05). FARI was weakly associated with NLR and PLR. FARI and PNI had a weak negative association. Multivariate analysis showed that the NIH risk category and FARI were independent prognostic predictors for worse outcomes concerning RFS in GIST patients. In the high-risk subgroup, patients with low FARI also had a more prolonged RFS than patients with high FARI (P <0.05). The nomogram had a concordance probability of 0.802 (SE 0.025). Nomogram predictions were well-calibrated. Concordance probabilities of the nomogram were better than NIH risk classification system [0.802 [0.025] vs. 0.737 [0.024], p < 0.01].

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Section: Discussionmentioning

confidence: 99%

Fibrinogen/Albumin Ratio Index Is an Independent Prognosis Predictor of Recurrence-Free Survival in Patients After Surgical Resection of Gastrointestinal Stromal Tumors

Cao

Cui

et al. 2020

Front. Oncol.

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“…Only limited evidence exists supporting the use of ATIII concentrates in either primary prevention or management following a VTE event (Hunault-Berger 2008). Further, direct oral anticoagulants (DOACs) (dabigatran, rivaroxaban, apixaban, and edoxaban) are potentially a better alternative to LMWH, as they act independently of ATIII and can be administered orally (Sibson 2018), albeit the bleeding risk needs to be balanced against the limited number of approved specific antidotes for DOACs. Consensus suggests that full dose thromboprophylaxis should be administered and is without excessive bleeding risk, when the platelet count is > 50 x 10 9 /L (Watson 2015).…”

Section: Description Of the Interventionmentioning

confidence: 99%

Prophylaxis of thromboembolism during therapy with asparaginase in adults with acute lymphoblastic leukaemia

Rank

Lynggaard

Als‐Nielsen

et al. 2020

Cochrane Database of Systematic Reviews

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“…Coagulation should always be checked at diagnosis,12 although the correlation between serious haemorrhage, coagulopathy or the use of prophylactic plasma is questionable 13. When considering correction of abnormal clotting results in the absence of bleeding, it is important to consider the potential risks of administering plasma components.…”

Section: Complications and Managementmentioning

confidence: 99%

Fifteen-minute consultation: Initial management of suspected acute leukaemia by non-specialists

Behjati¹,

Ruffle²,

Dickens

2019

Arch Dis Child Educ Pract Ed

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Leukaemia is the most common cancer of childhood. Most children with a new diagnosis of leukaemia are clinically stable at initial presentation. However, there are a number of life-threatening complications that have to be considered and monitored for. These complications include sepsis, tumour lysis syndrome, mediastinal masses, bleeding and pain. The aim of this article is to equip the general paediatrician with a framework for managing children with suspected leukaemia, prior to transfer to the primary treatment centre. The presentation, diagnosis and definitive treatment of acute leukaemia is not in the remit of this article.

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BSH Guideline: management of thrombotic and haemostatic issues in paediatric malignancy

Cited by 18 publications

References 117 publications

Fibrinogen/Albumin Ratio Index Is an Independent Prognosis Predictor of Recurrence-Free Survival in Patients After Surgical Resection of Gastrointestinal Stromal Tumors

Fibrinogen/Albumin Ratio Index Is an Independent Prognosis Predictor of Recurrence-Free Survival in Patients After Surgical Resection of Gastrointestinal Stromal Tumors

Prophylaxis of thromboembolism during therapy with asparaginase in adults with acute lymphoblastic leukaemia

Fifteen-minute consultation: Initial management of suspected acute leukaemia by non-specialists

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