<scp>Brain</scp>–<scp>immune</scp>–<scp>gut</scp> benefits with early life supplementation of milk fat globule membrane

Mohamed, Hamid Jan Jan; Lee, Eric Kim Hor; Woo, Kent Chee Keen; Sarvananthan, Rajini; Lee, Yeong Yeh; Zabidi-Hussin, Z A M H

doi:10.1002/jgh3.12775

Cited by 12 publications

(2 citation statements)

References 49 publications

(150 reference statements)

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“…The normality of the data was checked with the Shapiro-Wilk test. The total breast milk data were divided into membrane lipids and storage lipids based on nomenclature for the milk fat globule composition for further statistical analysis 16 . The workflow of methodology described in figure 1.…”

Section: Discussionmentioning

confidence: 99%

Exploring the impacts of human breast milk functional lipidome on infant health and growth outcomes in early life using lipid bioinformatics

Ganeshalingam,

Cheema,

Wagner

et al. 2024

Preprint

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Human breast milk lipidome is complex, and how changes in the functional lipid metabolism converge systematically to alter infants' health outcomes is poorly understood. We used human breast milk and infant-mother dyads as a test system to demonstrate how the application of improved lipid bioinformatics can be effective in discerning systematic changes in functional lipid metabolism providing novel discoveries of how lactational programming in early life can influence infant health and growth outcomes. The study consisted of 40 mother-infant dyads where breast milk, maternal diet, infant anthropometrics [fat mass index (FMI), length z score, BMI z score, fat-free mass index (FFMI)], and infant atopic disease outcome (ear infection, cold, wheezing, diarrhea, and eczema) were collected at one and four months postpartum. Integrated Lipid Bioinformatics analyses were conducted using XLSTAT, Metaboanalyst 5.0. R software, Lipid Search, Xcalibur, and Cytoscape software. The results showed breast milk lipidome ordinated into distinct clusters based on maternal BMI status, and differences in developmental and atopic disease outcomes following redundancy analysis. Specifically, lipids from obese mothers clustered with FMI and eczema, while lipids from non-obese mothers clustered with FFM and wheezing. Receiver operating analysis was effective in identifying potential lipid biomarkers that were significantly associated with infant FMI, FFMI, and eczema during early life. Sphingolipid and glycerophospholipid pathways were significantly associated with the altered breast milk lipidome impacting infant development and atopic disease outcome during the first year of life. The findings following the advanced lipid bioinformatics suggest that the breastmilk functional lipid metabolism appears to play a key role in lipid-mediated lactational programming influencing development and atopic disease outcome, and present opportunities for potential dietary intervention in early life. Keywords: Breast milk lipids, maternal body mass index, bioinformatics tools, Infant growth parameters, Infant Atopic Disease

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Section: Discussionmentioning

confidence: 99%

Exploring the impacts of human breast milk functional lipidome on infant health and growth outcomes in early life using lipid bioinformatics

Ganeshalingam,

Cheema,

Wagner

et al. 2024

Preprint

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show abstract

“…34,35 MFGM can be found both in human and ruminant milks, with similar compositions and structures. 36 The unique features of the MFGM (Fig. 2) and its possible role in neurodevelopment have been subject to numerous preclinical and clinical studies.…”

Section: Reviewmentioning

confidence: 99%

Milk fat globule membrane and its polar lipids: reviewing preclinical and clinical trials on cognition

Luque-Uría,

Calvo,

Visioli

et al. 2024

Food Funct.

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Technological and Health Effects of Butter By-products Rich in Phospholipids in Consumers’ Sustainable Diets

Ozcan,

Yilmaz-Ersan,

Dinkci

2024

Consumer Perceptions and Food

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Brain–immune–gut benefits with early life supplementation of milk fat globule membrane

Abstract: RajiniSarvananthan has received honoraria from Mead Johnson Nutrition (Malaysia) and Fonterra (Malaysia). Eric Lee has received honoraria from Abbott Nutrition (Malaysia) and Wyeth Nutrition (Malaysia) in the past 36 months. The other authors declare no conflict of interest.

Cited by 12 publications

References 49 publications

Exploring the impacts of human breast milk functional lipidome on infant health and growth outcomes in early life using lipid bioinformatics

Exploring the impacts of human breast milk functional lipidome on infant health and growth outcomes in early life using lipid bioinformatics

Milk fat globule membrane and its polar lipids: reviewing preclinical and clinical trials on cognition

Technological and Health Effects of Butter By-products Rich in Phospholipids in Consumers’ Sustainable Diets

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