BMP4 regulates asymmetric Pkd2 distribution in mouse nodal immotile cilia and ciliary mechanosensing required for left–right determination
Takanobu A. Katoh,
Tim Lange,
Yoshiro Nakajima
et al.
Abstract:BackgroundMouse nodal immotile cilia mechanically sense the bending direction for left–right (L–R) determination and activate the left‐side‐specific signaling cascade, leading to increased Nodal activity. Asymmetric distribution of Pkd2, a crucial channel for L–R determination, on immotile cilia has been reported recently. However, the causal relationship between the asymmetric Pkd2 distribution and direction‐dependent flow sensing is not well understood. Furthermore, the underlying molecular mechanism directi… Show more
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