<scp>BMI</scp> changes and the risk of lung cancer in male never‐smokers: A prospective cohort study

Wu, Zheng; Xie, Shuanghua; Wang, Fei; Chen, Shuohua; Su, Kai; Li, Fang; Cui, Hong; Cao, Wei; Yu, Yiwen; Qin, Chao; Zheng, Yadi; Dong, Xuesi; Yang, Zhuoyu; Luo, Zilin; Zhao, Liang; Xu, Yongjie; Chen, Hongda; Jiang, Li; Wang, Gang; Wu, Shouling; Dai, Min; Li, Ni; He, Jie

doi:10.1002/cam4.4546

Cited by 11 publications

(6 citation statements)

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“…Smoking, body mass index (BMI), asbestos, and air pollution were regarded as traditional risk factors for lung cancer (3,4). The molecular genetics of lung cancer are also important, and the development of malignant lung tumors seems to be due to the multistage molecular pathogenesis, as well as the accumulation and combination of genetic factors and abnormalities (5).…”

Section: Introductionmentioning

confidence: 99%

Causal associations between dietary antioxidant vitamin intake and lung cancer: A Mendelian randomization study

Zhao

Jin

2022

Front. Nutr.

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BackgroundOxidative stress is currently considered to be closely related to the occurrence of respiratory tumors, especially lung cancer. Many observational studies have shown that increased antioxidant intake can reduce the risk of lung cancer, but the results are still controversial. Therefore, we performed a two-sample Mendelian randomized (MR) analysis to clarify the causal relationship between antioxidant vitamins and lung cancer.MethodsTo assess the causal effect of dietary antioxidant vitamin intake on lung cancer, we conducted a two-sample MR analysis and we extracted single-nucleotide polymorphisms (SNPs) that are associated with antioxidants from genome-wide association studies (GWASs) of the UK biobank. We gathered summary data for lung cancer from the International Lung Cancer Consortium (ILCCO), including 11,348 cases and 15,861 controls, and applied the inverse-variance weighted (IVW) method as the primary MR analysis, and performed a sensitivity analysis to verify the results.ResultsThe results showed that higher dietary retinol intake was causally associated with lung cancer overall [odds ratio (OR) = 1.844, 95% CI, 1.359–2.502, p = 0.00009], squamous cell lung cancer (OR = 2.162, 95% CI, 1.117–4.183, p = 0.022), and lung adenocarcinoma (OR = 1.706, 95% CI, 1.084–2.685, p = 0.021). Additionally, carotene was positively correlated with lung adenocarcinoma (OR = 1.510, 95% CI, 1.002–2.276, p = 0.049). However, there was a non-significant relationship between the intake of other dietary antioxidants (vitamin C and vitamin E) and lung cancer.ConclusionOur research showed that dietary retinol intake has an adverse impact on lung cancer, and carotene might increase the risk of adenocarcinoma. This highlights the importance of revealing the underlying mechanisms of dietary antioxidant vitamins in lung cancer and delivers an important health message that dietary antioxidant vitamin intake may not be necessary for the prevention of lung cancer. It also provides a basis for future research.

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Section: Introductionmentioning

confidence: 99%

Causal associations between dietary antioxidant vitamin intake and lung cancer: A Mendelian randomization study

Zhao

Jin

2022

Front. Nutr.

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“…Associations of BMI with lung cancer have been reported across ethnic groups and across observational cohort studies; however, their findings are ambiguous. Based on relevant studies of the International Lung Cancer Consortium and the Chinese population, it was found that both an increase and a decrease in BMI could increase the risk of lung cancer and reduce the survival rate of lung cancer ( 48 , 49 ). Decreased BMI was also found to be associated with poorer overall survival of lung cancer, while weight gain increased the risk of death but was not statistically significant ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomization to explore the direct or mediating associations between socioeconomic status and lung cancer

Yang

Wang

et al. 2023

Front. Oncol.

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ObjectiveThe purpose of this study was to verify whether there are direct or mediated causal associations between socioeconomic status and lung cancer.MethodsPooled statistics were obtained from corresponding genome-wide association studies. The inverse-variance weighted, weighted median, MR−Egger, MR-PRESSO and contamination-mixture methods were used as supplements to Mendelian randomization (MR) statistical analysis. Cochrane’s Q value and the MR−Egger intercept were used for sensitivity analysis.ResultsIn the univariate MR analysis, household income and education had protective effects on overall lung cancer (income: P = 5.46×10-4; education: P = 4.79×10-7) and squamous cell lung cancer (income: P = 2.67×10-3; education: P = 1.42×10-10). Smoking and BMI had adverse effects on overall lung cancer (smoking: P = 2.10×10-7; BMI: P = 5.67×10-4) and squamous cell lung cancer (smoking: P = 5.02×10-6; BMI: P = 2.03×10-7). Multivariate MR analysis found that smoking and education were independent risk factors for overall lung cancer (smoking: P = 1.96×10-7; education: P = 3.11×10-3), while smoking was an independent risk factor for squamous cell lung cancer (P = 2.35×10-6). Smoking, education, and household income mediate the effect of BMI on overall lung cancer (smoking 50.0%, education 49.2%, income 25.3%) and squamous cell lung cancer (smoking 34.8%, education 30.8%, income 21.2%). Smoking, education, and BMI mediate the effect of income on overall lung cancer (smoking 13.9%, education 54.8%, BMI 9.4%) and squamous cell lung cancer (smoking 12.6%, education 63.3%, BMI 11.6%). Smoking, BMI, and income mediate the effect of education on squamous cell lung cancer (smoking 24.0%, BMI 6.2%, income 19.4%).ConclusionIncome, education, BMI, and smoking are causally associated with both overall lung cancer and squamous cell lung cancer. Smoking and education are independent association factors for overall lung cancer, while smoking is an independent association factor for squamous cell lung cancer. Smoking and education also play important mediating roles in overall lung cancer and squamous cell lung cancer. No causal relationship was found between multiple risk factors associated with socioeconomic status and lung adenocarcinoma.

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“…However, it is possible that a small residual number of confounding SNPs may still exist. To assess the association of each SNP with established common risk factors for lung cancer, including smoking, [ 42 ] alcohol consumption, [ 43 ] BMI, [ 44 ] hypertension, [ 45 ] diabetes, [ 46 ] and high cholesterol. [ 47 ] The Phenoscanner V2 website ( http://www.phenoscanner.medschl.cam.ac.uk/ ) was utilized.…”

Section: Methodsmentioning

confidence: 99%

The causal association between serum metabolites and lung cancer based on multivariate Mendelian randomization

Sun,

Chen,

Yan

et al. 2024

Medicine

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This study seeks to understand the causal association between serum metabolites and different lung cancer types, an area yet to be extensively studied. We Used a two-sample Mendelian randomization (TSMR) approach, utilizing 486 blood metabolites as exposures and 3 distinct lung cancer types genome-wide association studies datasets as outcomes. We employed inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode to estimate causal effects. We performed sensitivity analyses using Cochran Q test, MR-Egger intercept test, and MR-pleiotropy residual sum and outlier (MR-PRESSO). Linkage disequilibrium score (LDSC) analysis was conducted on the selected metabolites, and common confounding single nucleotide polymorphisms were eliminated using the human genotype-phenotype association Database. Metabolic pathway analysis was performed with MetaboAnalyst 5.0 software. Subsequently, a multivariate Mendelian randomization analysis was conducted to ascertain independent risk exposures. Our findings suggest independent risk factors for specific types of lung cancer: 7-methylxanthine and isoleucine for lung adenocarcinoma, cysteine and 1-arachidonoylglycerophosphocholine are identified as independent protective and risk factors for squamous lung cancer. Undecanoate (11:0) with Linoleate (18:2n6) showed a protective effect for small cell lung cancer. Additionally, 11 metabolic pathways were associated with lung cancer. This novel perspective offers a multidimensional understanding of lung cancer phenotypes, providing valuable guidance for identifying and screening of diverse lung cancer phenotypes.

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BMI changes and the risk of lung cancer in male never‐smokers: A prospective cohort study

Cited by 11 publications

References 35 publications

Causal associations between dietary antioxidant vitamin intake and lung cancer: A Mendelian randomization study

Causal associations between dietary antioxidant vitamin intake and lung cancer: A Mendelian randomization study

Mendelian randomization to explore the direct or mediating associations between socioeconomic status and lung cancer

The causal association between serum metabolites and lung cancer based on multivariate Mendelian randomization

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