BHAFT: Bayesian heredity‐constrained accelerated failure time models for detecting gene‐environment interactions in survival analysis
Na Sun,
Jiadong Chu,
Qida He
et al.
Abstract:In addition to considering the main effects, understanding gene‐environment (G × E) interactions is imperative for determining the etiology of diseases and the factors that affect their prognosis. In the existing statistical framework for censored survival outcomes, there are several challenges in detecting G × E interactions, such as handling high‐dimensional omics data, diverse environmental factors, and algorithmic complications in survival analysis. The effect heredity principle has widely been used in stu… Show more
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