<scp>BB‐UVA</scp> vs. <scp>NB‐UVB</scp> in the treatment of vitiligo: a randomized controlled clinical study (single blinded)

El‐Mofty, Medhat; Mostafa, Wedad Z.; Youssef, Randa; Elfangary, Mona M.; El-Ramly, Amany Z.; Mahgoub, Doaa; Fawzy, Marwa M.; El‐Hawary, M. F. S.

doi:10.1111/phpp.12061

Cited by 19 publications

(21 citation statements)

References 18 publications

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“…A total of seven RCTs involving 232 participants with vitiligo were included in this systematic review. Three studies focused on European population (16)(17)(18), two studies focused on African population (12,13) and two studies focused on Asian population (14,15).…”

Section: Study Characteristic and Quality Assessmentmentioning

confidence: 99%

“…Four trials conducted parallel controlled design (12)(13)(14)(15), two conducted half-side comparison design (17,18) and one was in within-patient design (16). The evaluation times of included studies ranged from 6 weeks to 9 months.…”

Section: Study Characteristic and Quality Assessmentmentioning

confidence: 99%

“…The evaluation times of included studies ranged from 6 weeks to 9 months. The treatment groups were respectively narrow-band ultraviolet B (NB-UVB) alone (12,13,(15)(16)(17), NB-UVB + oral minipulse (OMP) of corticosteroid (14) or NB-UVB + punch grafting (18). The control groups were ultraviolet A (UVA) (12,13), psoralens plus UVA (PUVA) + OMP (14), PUVA (15), 308-nm excimer light (EL) (16,17) or 308-nm excimer laser (EL) + punch grafting (18).…”

Section: Study Characteristic and Quality Assessmentmentioning

confidence: 99%

“…Then, corporated review excluded five studies not reporting the number of patients who achieved450,460 or475% re-pigmentation, and five studies not providing adequate and detailed statistics. Finally, seven RCTs were reserved and included in the study (12)(13)(14)(15)(16)(17)(18). The procedure was illustrated in Figure 1.…”

Section: Eligible Studiesmentioning

confidence: 99%

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Treatment of vitiligo with NB-UVB: A systematic review

Xiao

Sun

et al. 2014

Journal of Dermatological Treatment

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Section: Study Characteristic and Quality Assessmentmentioning

confidence: 99%

Section: Study Characteristic and Quality Assessmentmentioning

confidence: 99%

Section: Study Characteristic and Quality Assessmentmentioning

confidence: 99%

Section: Eligible Studiesmentioning

confidence: 99%

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Treatment of vitiligo with NB-UVB: A systematic review

Xiao

Sun

et al. 2014

Journal of Dermatological Treatment

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“…The lid of the culture dish was replaced by a quartz plate and HaCaT cells were exposed to BB-UVA radiation at doses of 1, 5 or 10 J/cm 2 with an emission centered at 365 nm or NB-UVB radiation at doses of 100, 200 or 400 mJ/cm 2 with an emission centered at 311 nm. Emissions were based on the results of a previous study (26). Cells without any treatment were used as a negative control.…”

Section: Methodsmentioning

confidence: 99%

The effects of phototherapy and melanocytes on keratinocytes

Tang

et al. 2018

Exp Ther Med

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Abstract. Phototherapy is widely used in the treatment of vitiligo. Previous studies have focused on the effects of ultraviolet (UV) radiation on melanocytes; however, the biological effects of phototherapy and melanocytes on keratinocytes remain to be elucidated. To investigate and assess the effects of clinically doses of broad band (BB)-UVA, narrow band (NB)-UVB and melanocytes on human keratinocytes in vitro, clinical doses of BB-UVA or NB-UVB radiation and human melanoma cell A375 co-culture were performed as stress divisors to HaCaT cells. Cell proliferation, expression of protease-activated receptor-2 (PAR-2) and nuclear factor E2-related factor 2 mRNA, lipid peroxidation and intracellular antioxidant level of keratinocytes were analyzed. It was demonstrated that UV radiation inhibited the proliferation of cells apart from following exposure to low dose (1 J/cm 2 ) UVA. Medium dose (5 J/cm 2 ) UVA radiation had no adverse effects on lipid peroxidation and increased antioxidant levels in HaCaT cells. Medium (200 mJ/cm 2 ) and high (400 mJ/cm 2 ) doses of UVB radiation induced cellular damage due to increased lipid peroxidation as indicated by levels of malondialdehyde. Furthermore, A375 co-culture treatment induced a similar effect on the lipid peroxidation of HaCaT as with low dose UVB radiation. Therefore, the results of the present study determined that clinical doses of BB-UVA and NB-UVB radiation had varying effects on proliferation and related protein levels in HaCaT cells. Co-culture with A375 had similar effects as those of low dose UVA and UVB radiation, in which the PAR-2 expression was significantly upregulated.

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Phototherapy for Vitiligo

et al. 2017

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IMPORTANCE References to the expected treatment response to phototherapy would be helpful in the management of vitiligo because phototherapy requires long treatment durations over several months.OBJECTIVE To estimate the treatment response of vitiligo to phototherapy.DATA SOURCES A comprehensive database search of MEDLINE, EMBASE, and the Cochrane library from inception to January 26, 2016, was performed for all prospective studies. The main keywords used were vitiligo, phototherapy, psoralen, PUVA, ultraviolet, NBUVB, and narrowband.STUDY SELECTION All prospective studies reporting phototherapy outcome for at least 10 participants with generalized vitiligo were included. Of 319 studies initially identified, the full texts of 141 studies were assessed for eligibility, and 35 were finally included in the analysis. Of these, 29 studies included 1201 patients undergoing narrowband UV-B (NBUVB) phototherapy, and 9 included 227 patients undergoing psoralen-UV-A (PUVA) phototherapy. DATA EXTRACTION AND SYNTHESISTwo reviewers independently extracted the following data: study design, number and characteristics of the participants, phototherapy protocol, and rate of repigmentation based on the quartile scale. Single-arm meta-analyses were performed for the NBUVB and PUVA groups. Sample size-weighted means were calculated using a random-effects model for the repigmentation rates of the included studies. MAIN OUTCOMES AND MEASURESThe primary outcomes were at least mild (Ն25%), at least moderate (Ն50%), and marked (Ն75%) responses on a quartile scale. Response rates were calculated as the number of participants who showed the corresponding repigmentation divided by the number of all participants enrolled in the individual studies. RESULTSThe meta-analysis included 35 unique studies (1428 unique patients). For NBUVB phototherapy, an at least mild response occurred in 62.1% (95% CI, 46.9%-77.3%) of 130 patients in 3 studies at 3 months, 74.2% (95% CI, 68.5%-79.8%) of 232 patients in 11 studies at 6 months, and 75.0% (95% CI, 60.9%-89.2%) of 512 patients in 8 studies at 12 months. A marked response was achieved in 13.0% (95% CI, 2.1%-23.9%) of 106 patients in 2 studies at 3 months, 19.2% (95% CI, 11.4%-27.0%) of 266 patients in 13 studies at 6 months, and 35.7% (95% CI, 21.5%-49.9%) of 540 patients in 9 studies at 12 months. For PUVA phototherapy, an at least mild response occurred in 51.4% (95% CI, 28.1%-74.7%) of 103 patients in 4 studies at 6 months and 61.6% (95% CI, 20.2%-100%) of 72 patients in 3 studies at 12 months. In the subgroup analyses, marked responses were achieved on the face and neck in 44.2% (95% CI, 24.2%-64.2%), on the trunk in 26.1% (95% CI, 8.7%-43.5%), on the extremities in 17.3% (95% CI, 8.2%-26.5%), and on the hands and feet in none after at least 6 months of NBUVB phototherapy. CONCLUSIONS AND RELEVANCELong-duration phototherapy should be encouraged to enhance the treatment response in vitiligo. The greatest response is anticipated on the face and neck.

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BB‐UVA vs. NB‐UVB in the treatment of vitiligo: a randomized controlled clinical study (single blinded)

Abstract: BB-UVA can be considered as an alternative treatment line for vitiligo.

Cited by 19 publications

References 18 publications

Treatment of vitiligo with NB-UVB: A systematic review

Treatment of vitiligo with NB-UVB: A systematic review

The effects of phototherapy and melanocytes on keratinocytes

Phototherapy for Vitiligo

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