<scp>B</scp>‐type natriuretic peptide levels are decreased by reducing dietary salt intake in patients with compensated heart failure with preserved ejection fraction

Sadanaga, Tsuneaki; Ando, Katsuyuki; Hirota, Shinichi; Mitamura, Hideo; Tsuchihashi, Takuya; Kohsaka, Shun; Fukuda, Keiichi; Ogawa, Satoshi

doi:10.1111/imj.12063

Cited by 10 publications

(5 citation statements)

References 16 publications

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“…Recently it has been reported that higher NT-proBNP is independently associated with the presence of OSA, 18 which is one of the causes of nocturia. 19 Excess sodium intake may also be involved in this association, because restriction of sodium intake has been reported to reduce BNP, 20 nocturnal urine volume, 21 and nocturia. 22 In addition, abnormal circadian BP patterns may at least partially be involved in the mechanism of the current results.…”

Section: Discussionmentioning

confidence: 99%

Association between NT‐proBNP and nocturia among community‐dwelling elderly males and females: A cross‐sectional analysis of the HEIJO‐KYO study

Okumura

Obayashi

Tai

et al. 2020

Neurourology and Urodynamics

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Aims: To investigate the association between B-type natriuretic peptide (BNP) and nocturia among community-dwelling males and females. Methods: A total of 1096 participants (mean age 71.9 ± 7.1 years, 518 [47.2%] males) were included in the study. The number of nocturnal voids was recorded in a self-reported urination diary, and nocturia was defined as two or more voids per night. Daytime serum concentration of the N-terminal fragment of BNP precursor (NT-proBNP) was measured. Multivariable logistic regression analysis was performed to determine the association between NT-proBNP and nocturia. Results: Nocturia was observed in 23.5% of females and 37.1% of males. Higher NT-proBNP (log pg/ml) was associated with nocturia in both gender groups (females: odds ratio [OR]: 1.67, 95% confidence interval [95% CI], 1.21-2.34, p = .002; males: OR: 1.26, 95% CI, 1.01-1.59, p = .046), independent of confounding variables including night-time blood pressure, mean voided volume, and chronic kidney disease. Although the increase in prevalence of nocturia with higher NT-proBNP was equivalent in both genders, some effect of gender on the relationship between NT-proBNP and nocturia was observed (p = .037). Nocturnal urine volume was also significantly and independently associated with NT-proBNP level (females: β = 32.9 ml, 95% CI, 5.63-60.2, p = .018; males: β = 34.6 ml, 95% CI, 9.40-59.9, p = .007). Conclusions: This study revealed higher serum NT-proBNP is significantly and independently associated with the prevalence of nocturia in both males and females. This is an exploratory cross-sectional study and the analyses are post hoc, so further research works are needed to clarify the causality and clinical value.

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Section: Discussionmentioning

confidence: 99%

Association between NT‐proBNP and nocturia among community‐dwelling elderly males and females: A cross‐sectional analysis of the HEIJO‐KYO study

Okumura

Obayashi

Tai

et al. 2020

Neurourology and Urodynamics

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“…Our data analysis showed that only 5 % HF patients fully adhered to the sodium restriction guideline (≤1500 mg per day). BNP and sodium intake are highly correlated [ 32 ]. Without fully complying with the sodium restriction guideline, it would be highly unlikely to observe significant changes in clinical biomarkers (BNP or urine sodium/ creatinine ratio).…”

Section: Discussionmentioning

confidence: 99%

Effects of a home-based activation intervention on self-management adherence and readmission in rural heart failure patients: the PATCH randomized controlled trial

Young

Hertzog

Barnason

2016

BMC Cardiovasc Disord

171

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BackgroundHeart failure (HF) patients discharged from rural hospitals have higher 30-day readmission rates. Self-management (SM) reduces readmissions, but adherence to SM guidelines is low in the rural HF population. We tested a home-based intervention to enhance patient activation and lead to improved SM adherence.MethodsIn this two-group, repeated measures randomized control trial, the main outcomes were patient reported and clinical outcomes associated with SM adherence, and all-cause readmission at 30, 90 and 180 days.ResultsThe study included 100 HF patients discharged from a rural critical access hospital. The intervention group received a 12-week SM training and coaching program delivered by telephone and tailored on subjects’ activation levels. At α = .10, the PATCH intervention showed significantly greater improvement compared to usual care in patient-reported SM adherence: weighing themselves, following a low-sodium diet, taking prescribed medication, and exercising daily (all p < .0005) at 3 and 6 months after discharge. In contrast, groups did not differ in physical activity assessed by actigraphy or in clinical biomarkers. Contrary to expectation, the 30-day readmission rate was significantly higher (p = .088) in the intervention group (19.6 %) than in the control group (6.1 %), with no differences at 90 or 180 days.ConclusionIt is feasible to conduct a randomized controlled trial in HF patients discharged from rural critical access hospitals. Significantly higher patient-reported SM adherence was not accompanied by lower clinical biomarkers or readmission rates. Further research is needed to understand mechanisms that influence outcomes and healthcare utilization in this population.Trial registrationClinical Trial Registration Information: ClinicalTrials.gov; NCT01964053.

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“…The significant decrease in NT‐proBNP in Group B does not appear to be related to changes in cardiac morphology because Diet Group B did not have significant reductions in left ventricular hypertrophy. The change in NT‐proBNP in Group B also might be related to variability in NT‐proBNP measurements, which has been shown in dogs, or to changes in dietary sodium intake . Dietary sodium (on a mg/100 kcal basis) decreased significantly for all 29 cats as a group, and individually for Diet Groups A and B.…”

Section: Discussionmentioning

confidence: 82%

“…The change in NT-proBNP in Group B also might be related to variability in NT-proBNP measurements, which has been shown in dogs, 14 or to changes in dietary sodium intake. 15 Dietary sodium (on a mg/100 kcal basis) decreased significantly for all 29 cats as a group, and individually for Diet Groups A and B. The current study did not measure absolute food intake, which would have allowed for calculation of sodium intake on a mg/day basis and is a limitation, but the fact that the median sodium content of the diet decreased significantly suggests that cats were likely to also have a decrease in their total daily sodium intake.…”

Section: Discussionmentioning

confidence: 99%

A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy

Freeman

Cunningham

Bulmer

2014

Veterinary Internal Medicne

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BackgroundDiet might influence progression of hypertrophic cardiomyopathy (HCM).ObjectiveTo investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM.AnimalsTwenty‐nine cats with HCM (International Small Animal Cardiac Health Council stage 1b) examined at a university teaching hospital.MethodsRandomized, placebo‐controlled trial. After physical examination, echocardiogram, and blood collection, cats were randomized to 1 of 3 diets, which varied in carbohydrate and fat content and ingredients. Measurements were repeated after 6 months.ResultsThere were no significant differences among the 3 groups at baseline. After 6 months, there were no significant changes in the primary endpoints, left ventricular free wall (Group A, P = .760; Group B, P = .475; Group C, P = .066) or interventricular septal thickness in diastole (Group A, P = .528; Group B, P = .221; Group C, P = .097). Group A had significant increases in BUN (P = .008) and cholesterol (P = .021), while Group B had significant increases in BUN (P = .008), cholesterol (P = .007), and triglycerides (P = .005), and significant decreases in NT‐proBNP (P = .013) and hs‐troponin I (P = .043). Group C had significant decreases in body weight (P = .021), left atrial dimension (P = .035), interventricular septal thickness in systole (P = .038), and liver enzymes (P = .034–.038).Conclusions and Clinical ImportanceThese data suggest that diet might influence some clinical, biochemical, and echocardiographic variables in cats with HCM.

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B‐type natriuretic peptide levels are decreased by reducing dietary salt intake in patients with compensated heart failure with preserved ejection fraction

Abstract: Changes in BNP levels were associated with changes in the estimated daily salt excretion in outpatients with compensated heart failure. Salt restriction may be beneficial for the management of patients with heart failure.

Cited by 10 publications

References 16 publications

Association between NT‐proBNP and nocturia among community‐dwelling elderly males and females: A cross‐sectional analysis of the HEIJO‐KYO study

Association between NT‐proBNP and nocturia among community‐dwelling elderly males and females: A cross‐sectional analysis of the HEIJO‐KYO study

Effects of a home-based activation intervention on self-management adherence and readmission in rural heart failure patients: the PATCH randomized controlled trial

A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy

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