AOP report: Development of an adverse outcome pathway for deposition of energy leading to cataracts
Emma Carrothers,
Meghan Appleby,
Vita Lai
et al.
Abstract:Cataracts are one of the leading causes of blindness, with an estimated 95 million people affected worldwide. A hallmark of cataract development is lens opacification, typically associated not only with aging but also radiation exposure as encountered by interventional radiologists and astronauts during the long‐term space mission. To better understand radiation‐induced cataracts, the adverse outcome pathway (AOP) framework was used to structure and evaluate knowledge across biological levels of organization (… Show more
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