AlzDiscovery: A computational tool to identify Alzheimer's disease‐causing missense mutations using protein structure information
Qisheng Pan,
Georgina Becerra Parra,
Yoochan Myung
et al.
Abstract:Alzheimer's disease (AD) is one of the most common forms of dementia and neurodegenerative diseases, characterized by the formation of neuritic plaques and neurofibrillary tangles. Many different proteins participate in this complicated pathogenic mechanism, and missense mutations can alter the folding and functions of these proteins, significantly increasing the risk of AD. However, many methods to identify AD‐causing variants did not consider the effect of mutations from the perspective of a protein three‐di… Show more
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