ALKing the flames of lung cancer immunosensitivity
Richard Bayliss,
Elżbieta Sarnowska,
Sharon Yeoh
et al.
Abstract:Immune checkpoint inhibitors (ICIs) are utilised in treating non‐small cell lung cancer (NSCLC) by enhancing the immune response against cancer cells. However, they are not effective against cancers with certain genetic alterations. A recent study by Mota et al. focussed on understanding why ALK+ NSCLC cancers are immune cold and making them more receptive to ICIs using a vaccine‐based approach. The study highlighted cell‐specific differences in the presentation of immunogenic peptides and the location of tumo… Show more
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