ABO blood group does not influence the level of anti‐SARS‐CoV‐2 antibodies in convalescent plasma donors

Abstract

Background The association of the ABO blood group with COVID‐19 disease has been confirmed by several studies, with the blood group A patients being more susceptible and prone to a more severe clinical course of the disease. Additionally, several authors also addressed the association of ABO‐types and the levels of anti‐SARS‐CoV‐2 antibodies in convalescents, mostly supporting a theory that the non‐O blood group convalescents present with higher levels of anti‐SARS‐CoV‐2 antibodies. Study Design and Methods Since previous findings were based on small convalescent cohorts, we quantified the anti‐SARS‐CoV‐2 antibody levels in a total of 3187 convalescent plasma donors with three commercial serological and one standard neutralizing antibody test. The majority of donors had undergone a mild form of the disease and the median time of sampling was 66 days after diagnosis. Results None of the antibody quantitation results showed any significant association with the ABO blood group types. The same result was evident in the subgroup of vaccinated individuals (n = 370) and the subgroups when stratified according to post‐COVID‐19 periods (0–60, 60–120, and 120–180 days). Conclusion In conclusion, we found no evidence to confirm that the ABO blood group types influence the level of SARS‐CoV‐2 antibody response in COVID‐19 convalescent plasma donors.

SARS-CoV-2 IgG Levels Allow Predicting the Optimal Time Span of Convalescent Plasma Donor Suitability

“…The level of IgG ratio values observed does not dependent on age, sex, ABO blood group or previous COVID-19 disease course. These findings are in line with other studies that previously demonstrated no significant correlation between SARS-CoV-2 antibody levels and sex, age and ABO blood group [ 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”

Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes

“…Although the connection between the ABO locus and SARS-CoV-2 susceptibility has been clearly established ( COVID-19 Host Genetics Initiative, 2021 ; COVID-19 Host Genetics Initiative, 2022 ), additional studies investigating the possible effect of the ABO blood type on the risk of SARS-CoV-2 infection, COVID-19 prognosis, and antibody response to anti-SARS-CoV-2 vaccine or infection yielded conflicting results ( Gil-Manso et al, 2022 ; Sgherza et al, 2022 ; Vicentini et al, 2022 ; Ziberna et al, 2022 ). Blood group O has been reported as a possible protective factor for disease progression ( Pereira et al, 2022 ), and recent studies have ascribed to the ABO locus a modifier role on the antibody titers, showing lower levels to B and O types compared to A and AB ( de Freitas Dutra et al, 2021 ).…”

Long-term dynamics of natural, vaccine-induced, and hybrid immunity to SARS-CoV-2 in a university hospital in Colombia: A cohort study

“…However, ABO-type has been shown to have no association with vaccine effectiveness 49 . A large study on 3,187 convalescent plasma donors found no evidence to con rm that the ABO type in uenced the level of SARS-CoV-2 antibody response 50 . Studies with larger sample sizes are required to con rm whether ABO-type in uences humoral responses after COVID-19 vaccination.…”