AAK1‐like: A putative pseudokinase with potential roles in cargo uptake in bloodstream form Trypanosoma brucei parasites
Jennifer A. Black,
Christen M. Klinger,
Leandro Lemgruber
et al.
Abstract:Selection and internalization of cargo via clathrin‐mediated endocytosis requires adaptor protein complexes. One complex, AP‐2, acts during cargo selection at the plasma membrane. African trypanosomes lack all components of the AP‐2 complex, except for a recently identified orthologue of the AP‐2‐associated protein kinase 1, AAK1. In characterized eukaryotes, AAK1 phosphorylates the μ2 subunit of the AP‐2 complex to enhance cargo recognition and uptake into clathrin‐coated vesicles. Here, we show that kinetopl… Show more
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