ScotCap – A large observational cohort study

MacLeod, Campbell; Hudson, Jemma; Brogan, Michelle; Cotton, SC; Treweek, S.; MacLennan, Graeme; Watson, A

doi:10.1111/codi.16029

Cited by 23 publications

(23 citation statements)

References 26 publications

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“…The FDA granted at-home administration amidst the global COVID-19 pandemic with already significant impact in endoscopy departments to delivery [ 26 , 27 ]. And while in China the capsule endoscopy group of the Society of Digestive Endoscopy published a recommendation on indications for urgent, semi-urgent and elective capsule endoscopy examination during the COVID-19 pandemic [ 28 ], Scotland was the first to implement a national rollout service in colon capsule endoscopy (CCE) [ 29 ]. CE has proven to be beneficial as a minimal-invasive, relatively safe approach with high diagnostic yield for vulnerable patient communities, e.g., pediatric populations [ 30 ], and it can be hoped for that benefits of outpatient solutions in combination with advances in telemedicine will translate to further, so far hard to reach populations worldwide [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

An Overview of the Evolution of Capsule Endoscopy Research—Text-Mining Analysis and Publication Trends

Steinmann

Valdivia

Nowak³

et al. 2022

Diagnostics

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There has been a steady increase (annual percentage growth rate of 19.2%, average of 18.3 citations per document) in capsule endoscopy (CE) publications from a global, interdisciplinary research community on a growing range of CE applications over the last 20+ years. We here present the status of CE as a field of research, tracing its evolution over time and providing insight into its potential for diagnostics, prevention and treatment of gastrointestinal (GI) tract diseases. To portray the development of the CE research landscape in the 2000–2021 time span, we analyzed 5764 scientific publications. Analyses were performed using the R language and environment for statistical computing and graphics and VOSviewer, a software developed for scientific literature analysis by scientometricians. The aim of this paper is to provide a wide comprehensive analysis of the trends in CE publications. We thus performed subgroup analysis on the selected papers, including indications, annual percentage growth rate, average citations per document, most publications from research areas/interdisciplinary field of the articles, geography, collaboration networks through institutions, specific clinical keywords and device type. The firm increase in CE publications over the last two decades highlights the overall strength of the technology in GI applications. Furthermore, the introduction to the field of artificial intelligence (AI) tools has been promoting a range of technological advances that keep on affecting the diagnostic potential of CE.

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Section: Discussionmentioning

confidence: 99%

An Overview of the Evolution of Capsule Endoscopy Research—Text-Mining Analysis and Publication Trends

Steinmann

Valdivia

Nowak³

et al. 2022

Diagnostics

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“…Currently there is an NHS CCE trial which will provide data on the utility of this intervention in the investigation of this patient population, however to date there is no direct evidence in the symptomatic population 133. Early indirect evidence from the SCOTCAP study suggest that CCE may be well-tolerated, although that there is a high rate of incomplete examination 134. There is a suggestion CCE may be considered in some lower risk populations whereby colonoscopy might be avoided.…”

Section: Investigation In Secondary Carementioning

confidence: 99%

“…133 Early indirect evidence from the SCOTCAP study suggest that CCE may be well-tolerated, although that there is a high rate of incomplete examination. 134 There is a suggestion CCE may be considered in some lower risk populations whereby colonoscopy might be avoided. In due course the NHS England trial will provide further relevant data to inform the use of CCE in the near future, however currently there is no published data of the diagnostic accuracy of CCE in people with symptoms of a suspected diagnosis of CRC.…”

Section: Investigation In Secondary Carementioning

confidence: 99%

Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG)

Monahan

Davies

Abulafi

et al. 2022

Gut

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Faecal immunochemical testing (FIT) has a high sensitivity for the detection of colorectal cancer (CRC). In a symptomatic population FIT may identify those patients who require colorectal investigation with the highest priority. FIT offers considerable advantages over the use of symptoms alone, as an objective measure of risk with a vastly superior positive predictive value for CRC, while conversely identifying a truly low risk cohort of patients. The aim of this guideline was to provide a clear strategy for the use of FIT in the diagnostic pathway of people with signs or symptoms of a suspected diagnosis of CRC. The guideline was jointly developed by the Association of Coloproctology of Great Britain and Ireland/British Society of Gastroenterology, specifically by a 21-member multidisciplinary guideline development group (GDG). A systematic review of 13 535 publications was undertaken to develop 23 evidence and expert opinion-based recommendations for the triage of people with symptoms of a suspected CRC diagnosis in primary care. In order to achieve consensus among a broad group of key stakeholders, we completed an extended Delphi of the GDG, and also 61 other individuals across the UK and Ireland, including by members of the public, charities and primary and secondary care. Seventeen research recommendations were also prioritised to inform clinical management.

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“… 22 ScotCap, using CCE in symptomatic and surveillance patients, reported a re-investigation rate of 63% and 70%, respectively. 11 There is a consensus that to improve patient experience and economy, the ideal investigation should be equivalent to OC, that is, a completion rate of greater than 90% and good visualisation of greater than 90%. A recent study introducing a new booster to reduce transit times showed promising results.…”

Section: Definitionsmentioning

confidence: 99%

The optimal use of colon capsule endoscopes in clinical practice

Bjørsum-Meyer

Koulaouzidis

Baatrup

2022

Therapeutic Advances in Chronic Disease

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Colon capsule endoscopy (CCE) has been available for nearly two decades but has grappled with being an equal diagnostic alternative to optical colonoscopy (OC). Due to the COVID-19 pandemic, CCE has gained more foothold in clinical practice. In this cutting-edge review, we aim to present the existing knowledge on the pros and cons of CCE and discuss whether the modality is ready for a larger roll-out in clinical settings. We have included clinical trials and reviews with the most significant impact on the current position of CCE in clinical practice and discuss the challenges that persist and how they could be addressed to make CCE a more sustainable imaging modality with an adenoma detection rate equal to OC and a low re-investigation rate by a proper preselection of suitable populations. CCE is embedded with a very low risk of severe complications and can be performed in the patient’s home as a pain-free procedure. The diagnostic accuracy is found to be equal to OC. However, a significant drawback is low completion rates eliciting a high re-investigation rate. Furthermore, the bowel preparation before CCE is extensive due to the high demand for clean mucosa. CCE is currently not suitable for large-scale implementation in clinical practice mainly due to high re-investigation rates. By a better preselection before CCE and the implantation of artificial intelligence for picture and video analysis, CCE could be the alternative to OC needed to move away from in-hospital services and relieve long-waiting lists for OC.

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ScotCap – A large observational cohort study

Cited by 23 publications

References 26 publications

An Overview of the Evolution of Capsule Endoscopy Research—Text-Mining Analysis and Publication Trends

An Overview of the Evolution of Capsule Endoscopy Research—Text-Mining Analysis and Publication Trends

Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG)

The optimal use of colon capsule endoscopes in clinical practice

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