Scorpio : Enhancing Embeddings to Improve Downstream Analysis of DNA sequences
Mohammad S. Refahi,
Bahrad A. Sokhansanj,
Joshua C. Mell
et al.
Abstract:Analyzing genomic and genetic sequences on the DNA level can be challenging due to the limited alphabet and sequence similarity varies depending on the labeling task, which makes tasks dependent on different evolutionary rates. In addition, metagenomic data poses significant challenges due to the vast diversity of taxa and genes within a microbiome. Here, we present Scorpio, a novel framework that employs triplet networks with contrastive learning, utilizing both pre-trained language models and k-mer frequency… Show more
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