Scoring systems and outcome of chronic kidney disease patients admitted in intensive care units

Abstract

The outcome of chronic kidney disease (CKD) patients admitted to the Intensive Care Unit (ICU) is difficult to predict. This study assessed the outcome of CKD patients admitted to the ICU and evaluated prediction of 30-day mortality using the Acute Physiology and Chronic Health Evaluation (APACHE II), Simplified Acute Physiology Score (SAPS II), and Sequential Organ Failure Assessment (SOFA) score. One hundred consecutive CKD patients admitted to the ICU at a tertiary care hospital, Ahmedabad between 2011 and 2013 were included prospectively. Data on demographics, indication for admission, cause of CKD, use of vasoactive drugs and mechanical ventilation (MV), mode of renal replacement therapy (RRT), and 30-day mortality were recorded. The APACHE II, SAPS II, and SOFA scores were calculated based on the admission characteristics. The mean APACHE II, SAPS II, and SOFA scores were 28.22 ± 7.53, 43.04 ± 16.40, and 10.39 ± 5.20, respectively, and area under receiver operating characteristics curve in predicting 30-day mortality were 0.961, 0.994, and 0.950, respectively. The scores were significantly higher in 30-day nonsurvivors as compared to survivors (P = 0.001). During the ICU stay, MV and vasoactive drugs were required in 57% and 67% of the patients, respectively, and the requirement was significantly greater in nonsurvivors as compared to survivors (P = 0.001). About 85% of patients were on intermittent hemodialysis and 15% of patients were on continuous venovenous hemodiafiltration. Sepsis was the main reason for hospital admission, and the mean length of stay in the ICU was 7.74 ± 5.34 days. The study indicates that all three scores (APACHE II, SAPS II, and SOFA) perform equally well and have equal diagnostic utility in predicting 30-day mortality.

Topical Application of Glycerine – Paraffin Combination in CKD-associated Pruritus and Uremic Xerosis: Study Protocol for a Randomized Control Trial

“…Glycerol keeps the skin hydrated and supple whereas Paraffin protect the skin from chemical irritant by improving its barrier function [17,18]. Studies on various aspects of chronic renal diseases were reported [19][20][21][22][23]. Studies from Global Injury were reviewed [24,25].…”

Balancing the Needs of Acute and Maintenance Dialysis Patients during the COVID-19 Pandemic

“…There is significant clinician workload associated with calculating CCI and SOFA scores to apply the algorithm to large dialysis programs and hospitals. We acknowledge that SOFA has limits for prognostication, but note its adoption in most ventilator triaging protocols in the United States (39) and reasonable discrimination among patients with AKI (40)(41)(42)(43)(44)(45). Our vetting process identified the importance of objective measures of prognosis; thus, we opted to use the CCI as an amendment to the strategy by White et al (16).…”

Predictive performance of the sequential organ failure assessment score for in‐hospital mortality in patients with end‐stage kidney disease in intensive care units: A multicenter registry in Japan

“…However, although the SOFA score has been validated across various populations in ICUs, there is no definitive consensus on its performance in predicting mortality in ICUs [19][20][21][22]. Actually, several previous studies have attempted to validate the discriminatory performance of this scoring system for in-hospital mortality prediction of patients with ESKD in ICUs [23][24][25]. However, inconsistent results were obtained by these studies, possibly due to the heterogeneity of the study populations and settings.…”