Scoring radiologic characteristics to predict proliferative potential in meningiomas

Abstract

We investigated the feasibility of using radiologic characteristics to predict the proliferative potential in meningiomas. Our statistical analysis revealed that the presence of peritumoral edema, an ambiguous brain-tumor border, and irregular tumor shape were significantly correlated with a higher MIB-1 staining index (SI) value. We developed the following scoring system for specific features in each tumor: peritumoral edema (tumor with edema = 1, tumor without edema = 0); brain-tumor border (tumor with any ambiguous border = 1, tumor circumscribed by a distinct rim = 0); and tumor shape (tumor with irregular shape = 1, tumor with smooth shape = 0). Using Spearman's correlation coefficient analysis, we found a significant correlation (P < 0.005) between total score calculated for each patient and SI value. Our findings suggest that the proliferative potential of meningiomas can be predicted using a less invasive preoperative examination focusing on the presence of peritumoral edema, ambiguous brain-tumor border, and irregular tumor shape.

Radiological Predictive Factors for Regrowth of Residual Benign Meningiomas

“…There was no correlation between the residual tumor volume and the period to re-treatment (r ＝ 0.041), or between MIB-1 index and the period to re-treatment (r ＝ -0.094). The mean total number of treatments after regrowth of residual tumor was 2.5 (2)(3)(4)(5)(6)(7)(8). No regrowth requiring treatment was observed in any patient throughout the follow-up period in Group A.…”

“…2,5,13,23,30) However, radiotherapy is not always effective, and may be dependent on the residual tumor size (volume). 4,11,17) If a residual tumor inevitably remains, its volume affects the later treatment.…”

Correlation between magnetic resonance imaging grading and pathological grading in meningioma

“…9,13,17,18,28 In clinical practice, the coexistence of several radiological features within 1 meningioma is not uncommon. Confusion frequently occurs because we do not know which finding is important and which is not.…”

“…22,24 However, this statement is not supported by other studies. 13,16,17 This problem occurs because different years were used as the dividing line in different reports. In this study, we use different years as the dividing line including 65, 70, and 75 years old.…”

“…9,13,17,18,28 In clinical practice, various combinations of radiological features usually appear within one meningioma. Thus, it is reasonable to make an exclusive and comprehensive assessment of all related clinical and radiological features Correlation between magnetic resonance imaging grading and pathological grading in meningioma for each patient.…”