Scoring hidradenitis suppurativa: How to simplify data collection?

Daoud, Mathieu; Benhadou, Farida; Njimi, Hassane; Jemec, Gregor B E; Daxhelet, Mathilde; White, Jonathan M. L.; Heudens, S; Karama, Jalila; Suppa, Mariano; Marmol, Véronique Del

doi:10.1111/jdv.18707

Cited by 2 publications

(4 citation statements)

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“…The questions and a complete clinical examination of the skin provide elements allowing the automatic calculation of 9 different scores through the registry [22]: HS Physician's Global Assessment (HS-PGA), Severity Assessment of HS Score (SAHS), Hidradenitis Suppurativa Clinical Response (HiSCR), IHS4, Hurley, Hurley Staging Refined (HSRef), Hidradenitis Suppurativa Severity Index (HSSI), and Sartorius 2003 and 2007. Moreover, the questionnaires also gather the clinical items required to classify patients into phenotype categories, according to all four classifications mentioned earlier [4,[12][13][14][15][16].…”

Section: Methodsmentioning

confidence: 99%

“…Severity of the Disease Scoring systems are useful in research and clinical practice to determine disease severity and establish a therapeutic plan. Using ERHS-Be, Daoud et al [22] established a rapid and automatic way to calculate 9 different scores in a patient. With his approach, two severity systems are studied in our cohort: the Hurley Staging and the IHS4.…”

Section: Inflammatory Comorbiditiesmentioning

confidence: 99%

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Belgian Patients of the European Registry for Hidradenitis Suppurativa (ERHS-Be): Data, Scores, and Phenotypes since 2015

Heudens,

Sarkis,

Daoud

et al. 2024

Dermatology

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Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease, characterized by painful and recurrent lesions in apocrine gland-bearing skin areas. It is a heterogeneous disease, which makes assessment and data collection difficult. Questionnaires with detailed items, such as the Belgian European Registry for Hidradenitis Suppurativa (ERHS-Be), are useful to study HS and its associated comorbidities. The aim of this registry is to uncover new factors associated with HS, understand HS patients’ clinical profiles and efficacy of treatments. Material and methods The ERHS-Be registry is based on questionnaires, with sections for socio-demographic data, medical and HS history, clinical examination and treatment plan. It allows identification of different clinical phenotypes and automatic calculation of severity scores. Results At present, 606 patients are included in the ERHS-Be (67% women, 33% men). Mean age at first visit is 38.5 years. Tobacco use is present in 72.6% of patients. A family history of HS is noted in 42% of patients. Comorbidities are documented in this cohort: depression is present in 43.8% of patients, arthritis in 27.8%, obesity in 31.5%, hypertension in 10.6%, diabetes mellitus in 6.4% and dyslipidemia in 12.4%. Moreover, 7.7% of patients suffer from IBD and 27.4% have a pilonidal sinus. History of severe acne is found in 32.1% of patients and psoriasis in 9.3%. Thirteen percent of women in our cohort suffer from polycystic ovarian syndrome. Severity of disease is quantified in 533 patients: for instance, Hurley I, II and III scores proportions are respectively 32.3%, 52.7% and 15%, while the mean IHS4 score is 5.2. This registry also enables determination of relative phenotype proportions in our cohort, according to different classifications. Conclusion The ERHS-Be questionnaires allow systematic and larger data collection, including detailed comorbidities, phenotypes and severity of disease. Analysis of this large database will contribute to a better understanding and management of HS, at a time where new therapeutic options are becoming available.

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Section: Methodsmentioning

confidence: 99%

Section: Inflammatory Comorbiditiesmentioning

confidence: 99%

Belgian Patients of the European Registry for Hidradenitis Suppurativa (ERHS-Be): Data, Scores, and Phenotypes since 2015

Heudens,

Sarkis,

Daoud

et al. 2024

Dermatology

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“…Firstly, the ERHS works by collecting the items needed for the scores, ( 6 ) so the investigator does not have to calculate the score in front of the patient. This not only avoids calculation errors, but also fixes the counting of lesions between scores (e.g., the number of draining fistulas in the IHS4 or in the SAHS is the same, the investigator only had to count them once).…”

Section: Methodsmentioning

confidence: 99%

“…These items can be elementary lesions (nodules, abscesses, fistulae, cords, follicular papules/pustules, comedos, multiple pyogenic granulomas), ( 5 ) quality of life data, or other objective/subjective measures. Many scores share the same criteria, which sometimes allows several scores to be calculated with the same clinical data ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Overview and comparison of the clinical scores in hidradenitis suppurativa: A real-life clinical data

et al. 2023

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IntroductionPartly due to its clinical heterogeneity, hidradenitis suppurativa (HS) is difficult to score accurately; illustrated by the large number of disease scores. In 2016, a systematic review by Ingram et al. reported the use of about thirty scores, and since then, this number has increased further. Our aim is twofold: to provide a succinct but detailed narrative review of the scores used to date, and to compare these scores with each other for individual patients.Materials and methodsThe review of the literature was done among articles in English and French, on Google, Google scholar, Pubmed, ScienceDirect and Cochrane. To illustrate the differences between scores, data from some Belgian patients included in the European Registry for HS were selected. A first series of patients compares the severity of the following scores: Hurley, Hurley Staging refined, three versions of Sartorius score (2003, 2007, 2009), Hidradenitis Suppurativa Physician Global Assessment (HS-PGA), International Hidradenitis Suppurativa Severity Scoring System (IHS4), Severity Assessment of Hidradenitis Suppurativa (SAHS), Hidradenitis Suppurativa Severity Index (HSSI), Acne Inversa Severity Index (AISI), the Static Metascore, and one score that is not specific to HS: Dermatology Life Quality Index (DLQI). A second set of patients illustrates how some scores change over time and with treatment: Hurley, Hurley Staging refined, Sartorius 2003, Sartorius 2007, HS-PGA, IHS4, SAHS, AISI, Hidradenitis Suppurativa Clinical Response (HiSCR), the very new iHS4-55, the Dynamic Metascore, and DLQI.ResultsNineteen scores are detailed in this overview. We illustrate that for some patients, the scores do not predictably and consistently correlate with each other, either in an evaluation of the severity at a time-point t, or in the evaluation of the response to a treatment. Some patients in this cohort may be considered responders according to some scores, but non-responders according to others. The clinical heterogeneity of the disease, represented by its many phenotypes, seems partly to explain this difference.ConclusionThese examples illustrate how the choice of a score can lead to different interpretations of the response to a treatment, or even potentially change the results of a randomized clinical trial.

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Scoring hidradenitis suppurativa: How to simplify data collection?

Cited by 2 publications

References 9 publications

Belgian Patients of the European Registry for Hidradenitis Suppurativa (ERHS-Be): Data, Scores, and Phenotypes since 2015

Belgian Patients of the European Registry for Hidradenitis Suppurativa (ERHS-Be): Data, Scores, and Phenotypes since 2015

Overview and comparison of the clinical scores in hidradenitis suppurativa: A real-life clinical data

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