Scopolamine patch reduces postoperative emesis in paediatric patients following strabismus surgery

Horimoto, Yoh; Tomie, Hisashi; K, Hanzawa; Nishida, Yuri

doi:10.1007/bf03007580

Cited by 46 publications

(32 citation statements)

References 21 publications

(2 reference statements)

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“…The 22-30% incidence of emetic symptoms in this study was low compared with the 41435% reported by other workers (Abramowitz et al 1983;Hardy et al 1986;Broadman et al 1990;Larsson & Johmarker 1990;Horimoto et al 1991). In this study, narcotics the postoperative period.…”

Section: Discussioncontrasting

confidence: 79%

Anticholinergic prophylaxis does not prevent emesis following strabismus surgery in children

Chisakuta

Mirakhur

1995

Pediatric Anesthesia

117

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One hundred and twenty-one children were studied in this prospective, randomized double-blind, placebo-controlled comparison of the effectiveness of anticholinergic prophylaxis for the prevention of emetic symptoms following strabismus surgery. The children were allocated to three groups, to receive placebo (n = 40), glycopyrrolate (n = 40) or atropine (n = 41). The incidence of intraoperative oculocardiac reflex (OCR) and of postoperative emetic symptoms for 24 h was recorded. The incidence of OCR was 55% in the placebo group compared with 5% and 2% in the glycopyrrolate and atropine groups respectively (P < 0.05). Thirty percent (12/40) of patients in the placebo group, 25% (10/40) in the glycopyrrolate group, and 22% (9/41) in the atropine group experienced nausea and/or vomiting (difference not significant). It is concluded that prophylactic administration of anticholinergic agents during strabismus surgery in children despite being effective against the occurrence of the oculocardiac reflex, does not reduce the incidence of emetic symptoms.

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Section: Discussioncontrasting

confidence: 79%

Anticholinergic prophylaxis does not prevent emesis following strabismus surgery in children

Chisakuta

Mirakhur

1995

Pediatric Anesthesia

117

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“…After a study on the short-term safety of use in children (aged 1-11y) where scopolamine has been used prophylactically as an anti-emetic after strabismus surgery, Horimoto et al (1991) state that the size of the existing patches should be reduced for children. In their study a quarter patch was used for children under 2 years old, and one-half in older children.…”

Section: Discussionmentioning

confidence: 99%

Visual side‐effects from transdermal scopolamine (hyoscine)

Firth

Walker

2006

Develop Med Child Neuro

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Transdermal scopolamine may be used to reduce drooling in children with disabilities. Side‐effects include dilated pupils and a reduction in the near point of accommodation (the closest point at which clear vision is possible). Two male children with epilepsy, one with spinal dysraphism (aged 7y 6mo) and one with cerebral palsy (aged 5y 8mo), who have undergone treatment for drooling with transdermal scopolamine are described. Near visual acuity was reduced, and both children showed dilated pupils with reduced or no response to light. These responses became normal on cessation of the scopolamine patch. As the effect of this drug may be cumulative, and many patients are unable to communicate difficulties, clinicians need to be aware of these possible side‐effects.

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“…In the case of transdermal patches, this is ideally accomplished by using the availability of different sized patches or, in some cases, by cutting an original patch to an appropriate size. The use of transdermal scopolamine patches to treat post-operative emesis in 25 (1-11 y) paediatric patients following strabismus surgery has been described [112]. One quarter of the original patch was used for patients under 2 years, and half a patch for older patients.…”

Section: Paediatric Use Of Transdermal Therapeutic Systems (Tts)mentioning

confidence: 99%