Scopolamine does not impact declarative and motor memory consolidation across a night of sleep or a day of wakefulness

Does Sleep Protect Memories Against Interference? A Failure to Replicate

“…A previous study from our lab found that providing participants an extrinsic reward for performance ($1 per correct answer) resulted in better recall of visual paired associates (picture pairs) compared to no reward, but that this reward effect was not different between sleep and wake participants [22]. We have also shown that increased intrinsic motivation (the desire to do well even in the absence of extrinsic rewards), measured by responses to items from the Intrinsic Motivation Inventory [24] used in the present study correlated with better acquisition of visual paired associates (picture-object pairs) at training, and also with change in performance from training to retest (retention) [23]. In the present study, we observed a similar positive correlation between intrinsic motivation and training performance.…”

“…More recently, our lab has examined intrinsic motivation (the desire to perform a task well for its own sake) as a potential modulator of the sleep-wake differences in memory. One study from our lab showed that intrinsic motivation correlated with better task acquisition and consolidation (change in performance from training to retest), but that the sleep/wake effect was not impacted by intrinsic motivation [23]. As in that study, we analyzed four items from the Intrinsic Motivation Inventory [24,25] and their relationship to memory performance following sleep and wake.…”

“…This represented a methodological improvement over the study [4], in which sleep/wake condition and interference condition were treated as between-subjects variables, decreasing the statistical power of the design. Stimuli were randomly selected two-syllable words from the Toronto Word Pool [26], used to create three lists of 20 word pairs (A 1-20 -B 1-20 , A 21-40 -B [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] , A 41-60 -B 41-60 ) and a fourth list used during the interference learning phase (A 41-60, C 1-20 ) (see Figure 1). Word pairs were "matched for imageability, frequency of use, and concreteness" [8].…”

Does sleep protect memories against interference? A failure to replicate

“…A previous study from our lab found that providing participants an extrinsic reward for performance ($1 per correct answer) resulted in better recall of visual paired associates (picture pairs) compared to no reward, but that this reward effect was not different between sleep and wake participants [25]. We have also shown that increased intrinsic motivation (the desire to do well even in the absence of extrinsic rewards), measured by responses to items from the Intrinsic Motivation Inventory [27] used in the present study, correlated with better acquisition of visual paired associates (picture-object pairs) at training, and also with change in performance from training to retest (retention) [26]. In the present study, we observed a similar positive correlation between intrinsic motivation and training and retest performance.…”

“…More recently, our lab has examined intrinsic motivation (the desire to perform a task well for its own sake) as a potential modulator of the sleepwake differences in memory. One study from our lab showed that intrinsic motivation correlated with better task acquisition and consolidation (change in performance from training to retest), but was not associated with better performance in the sleep (v. wake) participants [26]. As in that study, we analyzed four items from the Intrinsic Motivation Inventory [27,28] and their relationship to memory performance following sleep and wake.…”