Scopolamine and amphetamine produce similar decision-making deficits on a rat gambling task via independent pathways

Silveira, Mason M.; Malcolm, Emma; Shoaib, Mohammed; Winstanley, Catharine A.

doi:10.1016/j.bbr.2014.12.029

Cited by 23 publications

(26 citation statements)

References 67 publications

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“…Whereas nicotine increases risky choice in the PDT (Mendez, Gilbert, Bizon, & Setlow, 2012), it increases risk aversion in the RDT (Mitchell et al, 2011), although early-life administration of nicotine does not affect behavior in this task (Mitchell et al, 2012). Nicotine does not affect performance in the rGT (Silveira et al, 2015). Although stimulating nicotinic receptors alters risky choice, albeit in different ways across the PDT and the RDT, blocking nicotinic receptors does not alter risky choice in either the PDT or in the rGT (Mendez et al, 2012; Silveira et al, 2015).…”

Section: Neurochemical Underpinnings Of Risky Choicementioning

confidence: 93%

“…Nicotine does not affect performance in the rGT (Silveira et al, 2015). Although stimulating nicotinic receptors alters risky choice, albeit in different ways across the PDT and the RDT, blocking nicotinic receptors does not alter risky choice in either the PDT or in the rGT (Mendez et al, 2012; Silveira et al, 2015).…”

Section: Neurochemical Underpinnings Of Risky Choicementioning

confidence: 93%

“…Amphetamine, which is known to reverse dopamine, as well as norepinephrine, transporters, differentially alters risky choice across the various tasks described above. Specifically, amphetamine increases risky choice in the PDT (Floresco & Whelan, 2009; Oinio et al, 2017; St Onge, Chiu, & Floresco, 2010; St Onge & Floresco, 2009) and decreases optimal choice in the rGT, as rats are less willing to choose the P2 option (Barrus & Winstanley, 2016; Silveira, Malcom, Shoaib, & Winstanley, 2015; Zeeb et al, 2009; Zeeb et al, 2013). However, amphetamine typically decreases risky choice in the RDT (Mitchell, Vokes, Blakenship, Simon, & Setlow, 2011; Orsini et al, 2016; Simon et al, 2009; Simon et al, 2011; but see Orsini et al, 2018).…”

Section: Neurochemical Underpinnings Of Risky Choicementioning

confidence: 99%

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Examining the neurochemical underpinnings of animal models of risky choice: Methodological and analytic considerations.

Yates

2019

Experimental and Clinical Psychopharmacology

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Because risky choice is associated with several psychiatric conditions, recent research has focused on examining the underlying neurochemical processes that control risk-based decision making. Not surprisingly, several tasks have been developed to study the neural mechanisms involved in risky choice. The current review will briefly discuss the major tasks used to measure risky choice and will summarize the contribution of several major neurotransmitter systems to this behavior. To date, the most common measures of risky choice are the probability discounting task (PDT), the risky decision task (RDT), and the rat gambling task (rGT). Across these three tasks, the contribution of the dopaminergic system has been most studied, although the effects of serotonergic, adrenergic, cholinergic, and glutamatergic ligands will be discussed. Drug effects across these tasks have been inconsistent, which makes determining the precise role of neurotransmitter systems in risky choice somewhat difficult. Furthermore, procedural differences can modulate drug effects in these procedures, and the way data are analyzed can alter the interpretations one makes concerning pharmacological manipulations. By taking these methodological/analytic considerations into account, we may better elucidate the neurochemistry of risky decision making.

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Section: Neurochemical Underpinnings Of Risky Choicementioning

confidence: 93%

Section: Neurochemical Underpinnings Of Risky Choicementioning

confidence: 93%

Section: Neurochemical Underpinnings Of Risky Choicementioning

confidence: 99%

See 1 more Smart Citation

Examining the neurochemical underpinnings of animal models of risky choice: Methodological and analytic considerations.

Yates

2019

Experimental and Clinical Psychopharmacology

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“…Accumulating evidence suggests that d‐amphetamine and ephedrine might counteract the sedative side effects of scopolamine and antihistamines, but at the risk of drug addiction and counterbalancing the vestibular suppression effect (Table ). Nevertheless, scopolamine used in combination with d‐amphetamine against MS should be cautioned, for scopolamine impairs decision‐making and motivational behavior similar to the effect produced by amphetamine . Modafinil, a potential substitute of amphetamine, significantly enhanced the efficacy of scopolamine when used in combination in rodents , but failed to prevent MS in humans when used alone .…”

Section: Motion Sickness Medicationsmentioning

confidence: 99%

Motion Sickness: Current Knowledge and Recent Advance

et al. 2015

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Motion sickness (MS) is a common physiological response to real or virtual motion. Numerous studies have investigated the neurobiological mechanism and the control measures of MS. This review summarizes the current knowledge about pathogenesis and pathophysiology, prediction, evaluation, and countermeasures of MS. The sensory conflict hypothesis is the most widely accepted theory for MS. Both the hippocampus and vestibular cortex might play a role in forming internal model. The pathophysiology focuses on the visceral afference, thermoregulation and MS-related neuroendocrine. Single-nucleotide polymorphisms (SNPs) in some genes and epigenetic modulation might contribute to MS susceptibility and habituation. Questionnaires, heart rate variability (HRV) and electrogastrogram (EGG) are useful for diagnosing and evaluating MS. We also list MS medications to guide clinical practice. Repeated real motion exposure and combined visual-vestibular interaction training accelerate the progress of habituation. Behavioral and dietary countermeasures, as well as physiotherapy, are also effective in alleviating MS symptoms.

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“…However, numerous studies have shown that choice patterns on the rGT are mutable by a variety of monoaminergic and catecholaminergic ligands (e.g., Adams et al 2017a;Baarendse et al 2012;Di Ciano et al 2018;Silveira et al 2015;Zeeb et al 2009). Choice on the uncued version of the rGT is sensitive to reinforcer devaluation, as would be expected if behavior was truly goal-directed rather than habitual or automatic .…”

Section: Discussionmentioning

confidence: 99%

Increased motor impulsivity in a rat gambling task during chronic ropinirole treatment: potentiation by win-paired audiovisual cues

et al. 2019

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Rationale Chronic administration of D 2/3 receptor agonists ropinirole or pramipexole can increase the choice of uncertain rewards in rats, theoretically approximating iatrogenic gambling disorder (iGD). Objectives We aimed to assess the effect of chronic ropinirole in animal models that attempt to capture critical aspects of commercial gambling, including the risk of losing rather than failing to gain, and the use of win-paired sensory stimuli heavily featured in electronic gambling machines (EGMs). Methods Male Long-Evans rats learned the rat gambling task (rGT; n = 24), in which animals sample between four options that differ in the magnitude and probability of rewards and time-out punishments. In the cued rGT (n = 40), reward-concurrent audiovisual cues were added that scaled in complexity with win size. Rats were then implanted with an osmotic pump delivering ropinirole (5 mg/kg/day) or saline for 28 days. Results Chronic ropinirole did not unequivocally increase preference for more uncertain outcomes in either the cued or uncued rGT. Ropinirole transiently increased premature responses, a measure of motor impulsivity, and this change was larger and more long-lasting in the cued task. Conclusions These data suggest that explicitly signaling loss prevents the increase in preference for uncertain rewards caused by D 2/3 receptor agonists observed previously. The ability of win-paired cues to amplify ropinirole-induced increases in motor impulsivity may explain why compulsive use of EGMs is particularly common in iGD. These data offer valuable insight into the cognitivebehavioral mechanisms through which chronic dopamine agonist treatments may induce iGD and related impulse control disorders.

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Scopolamine and amphetamine produce similar decision-making deficits on a rat gambling task via independent pathways

Cited by 23 publications

References 67 publications

Examining the neurochemical underpinnings of animal models of risky choice: Methodological and analytic considerations.

Examining the neurochemical underpinnings of animal models of risky choice: Methodological and analytic considerations.

Motion Sickness: Current Knowledge and Recent Advance

Increased motor impulsivity in a rat gambling task during chronic ropinirole treatment: potentiation by win-paired audiovisual cues

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