Scopolamine administration in repeat breeder cows on the day of heat

Rizzo, Annalisa; Lillo, Edoardo; Ceci, Edmondo; Maggiolino, Aristide; Cicirelli, Vincenzo; Sciorsci, Raffaele Luigi

doi:10.1016/j.theriogenology.2022.10.003

Cited by 1 publication

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scopolamine, a parasympatholytic drug, has been proposed as a treatment to modulate uterine contractility and increase the conception rate in RBC cases with hormonal alterations or contractile and biochemical deficits. A recent study reported a significant increase in conception rates in RBCs treated with scopolamine (80%) compared to non-treated RBCs (25%) when administered on the day of estrus (12 h before AI) [ 125 ].…”

Section: Therapeutic Control Of the Estrous Cyclementioning

confidence: 99%

Current Insights in the Repeat Breeder Cow Syndrome

Marı́n

Arias

2023

Animals

View full text Add to dashboard Cite

Cows can have difficulties becoming pregnant, and in certain cases, these reproductive failures do not have an evident cause. Furthermore, when these failures are repeated three or more times with estrous cycles of normal duration and in the absence of evident clinical signs, it is considered repeat breeder cow (RBC) syndrome. A substantive incidence of RBC syndrome has been reported all over the world, which severely affects the farm economy. This paper reviews those studies particularly focused on RBC syndrome from 2000 to 2023 but also includes consolidated information until this date. Hormonal imbalances, undetectable oviductal or uterine defects, or poor oocyte or embryo quality have been reported as causes of RBC syndrome, while subclinical endometritis has been considered a relevant causal agent. However, it is unresolved why this condition is recurrent in certain animals, despite the implementation of corrective management actions or treatments. Recent studies evaluate the putative role of certain genes, factors, hormones, or proteins in the pathogenesis of RBC syndrome. Numerous risk factors contribute to the appearance of this syndrome, and some of them could be mitigated to partially prevent this infertility, while others cannot be changed. Due to the complexity of this syndrome, it is important to increase knowledge about the mechanisms involved, develop new diagnostic tools to differentiate causal agents, and implement new treatments to restore fertility. There is consensus about the huge repercussions of this syndrome on farm profitability, but further studies are now needed to describe its economic impact.

show abstract

Section: Therapeutic Control Of the Estrous Cyclementioning

confidence: 99%