Scoping the international impact from four independent national dermatology trials

Abstract

Background. Research impact describes whether and how research results in wider benefits to society beyond academic publication. Little is known about translation of clinical trial research into dermatological practice. Aim. We scoped international impact from four independently funded clinical trials published by our group over the past 10 years. Methods. This was a scoping survey of 35 international colleagues from 22 countries followed by a narrative summary of emergent themes. Results. All recipients kindly responded to the survey. At least 20 emergent themes were identified, which broadly included: (i) interest and enthusiasm in the concept of trying to document clinical trial impact; (ii) direct impacts such as adoption of the drug as tested and recommended from the trial results, including more confidence using the drug in slightly different ways for the same condition; (iii) the finding that trial impact was dependent on factors such as drug availability and country-specific disease patterns; and (iv) the educational value of good trial design for journal club discussions and improving future clinical trial designs in dermatology. Our survey suggests that uptake into clinical practice was surprisingly rapid and widespread. Conclusion.Clinical trial research is of little use unless findings are translated into clinical practice for patient benefit. Our international scoping survey suggests that independent clinical trials that address important questions identified by the dermatology community have substantial, diverse and far-reaching impacts on dermatological practice.

Do open-access dermatology articles have higher citation counts than those with subscription-based access?

“…Citation counts and Altmetric scores are only a rough proxy for the actual scientific impact of an article, and perhaps scientific impact in dermatology is better measured by translation into clinical practice e.g. the direct impact of adoption of a drug tested and recommended in a clinical trial [ 36 ].…”

Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials

“…24 Some widely used interventions, such as silk clothing for eczema, 25 failed to show any benefit, allowing the NHS to cease investment in ineffective treatments. UK DCTN trials are also influential internationally, 33 with direct impacts such as adoption of the trial drug, or giving clinicians more confidence in using drugs in slightly different ways for the same condition. The educational value of good trial design for journal club discussions has also been highlighted.…”