2022
DOI: 10.1002/phar.2748
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Scoping review of rational polytherapy in patients with drug‐resistant epilepsy

Abstract: There is a paucity of literature regarding the optimal selection of combination antiseizure medications (ASMs) for drug-resistant epilepsy (DRE). The aim of this scoping review is to evaluate current evidence related to "rational polytherapy" among adults with DRE. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-SCr) guidelines, PubMed, ProQuest, CINAHL, and Cochrane databases were searched using DRE-and polytherapy-related keywords. The exclusion criter… Show more

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Cited by 7 publications
(3 citation statements)
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References 54 publications
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“…The number of ASMs was not significantly correlated with QoL. There is a lack of consensus in the literature about the roles of monotherapy and polytherapy [ 39 ]. Our data suggest that poor QoL related to pharmacotherapy is due to the side effects of the medications, regardless of the number of ASMs, and patients receiving polytherapy have a higher risk of adverse events.…”
Section: Discussionmentioning
confidence: 99%
“…The number of ASMs was not significantly correlated with QoL. There is a lack of consensus in the literature about the roles of monotherapy and polytherapy [ 39 ]. Our data suggest that poor QoL related to pharmacotherapy is due to the side effects of the medications, regardless of the number of ASMs, and patients receiving polytherapy have a higher risk of adverse events.…”
Section: Discussionmentioning
confidence: 99%
“…DRE is present in about 30% of children with epilepsy, with an incidence of around 15% [ 12 ]. Despite this being widely practised, there is currently little evidence on how to optimally combine ASMs in the course of polytherapy [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…The level of QOL is negatively correlated with the frequency of seizures in most studies [3][4][5][6]. There are numerous clinical factors reported by other authors that have an impact on the QOL, such as the duration of the disease [7], the age of onset [8], the type of seizures [9] or the number of anti-seizure medications (ASM) [10]; however, the determining role of these variables differs between countries.…”
Section: Introductionmentioning
confidence: 99%