Scoping review of clinical practice guidelines on the management of benign liver tumours

Haring, Martijn P D; Cuperus, Frans J. C.; Duiker, Evelien W.; Haas, Robbert J. de; Meijer, Vincent E de

doi:10.1136/bmjgast-2020-000592

Cited by 8 publications

(9 citation statements)

References 60 publications

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“…It is probable that these specificities will guide the establishment of the future guidelines for the management for HCAs. With the aim of building guidelines in mind, it is important to collect standardized clinical and imaging data that led to the clinical management decision in each case [ 65 ].…”

Section: Frequently Asked Questionsmentioning

confidence: 99%

Etiology, Pathogenesis, Diagnosis, and Practical Implications of Hepatocellular Neoplasms

Hytiroglou

Bioulac‐Sage

Theise

et al. 2022

Cancers

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Hepatocellular carcinoma (HCC), a major global contributor of cancer death, usually arises in a background of chronic liver disease, as a result of molecular changes that deregulate important signal transduction pathways. Recent studies have shown that certain molecular changes of hepatocarcinogenesis are associated with clinicopathologic features and prognosis, suggesting that subclassification of HCC is practically useful. On the other hand, subclassification of hepatocellular adenomas (HCAs), a heterogenous group of neoplasms, has been well established on the basis of genotype–phenotype correlations. Histologic examination, aided by immunohistochemistry, is the gold standard for the diagnosis and subclassification of HCA and HCC, while clinicopathologic correlation is essential for best patient management. Advances in clinico-radio-pathologic correlation have introduced a new approach for the diagnostic assessment of lesions arising in advanced chronic liver disease by imaging (LI-RADS). The rapid expansion of knowledge concerning the molecular pathogenesis of HCC is now starting to produce new therapeutic approaches through precision oncology. This review summarizes the etiology and pathogenesis of HCA and HCC, provides practical information for their histologic diagnosis (including an algorithmic approach), and addresses a variety of frequently asked questions regarding the diagnosis and practical implications of these neoplasms.

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Section: Frequently Asked Questionsmentioning

confidence: 99%

Etiology, Pathogenesis, Diagnosis, and Practical Implications of Hepatocellular Neoplasms

Hytiroglou

Bioulac‐Sage

Theise

et al. 2022

Cancers

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“…Hepatic hemangioma is the most common benign tumor of the liver. Autopsy data have shown that its frequency is 0.4–7.3% ( 1 , 13 , 14 ). Mocchegiani et al ( 15 ) reviewed the data of more than 83,000 patients who underwent abdominal CT and/or MRI, and found that the prevalence of hepatic hemangioma was 2.5%.…”

Section: Discussionmentioning

confidence: 99%

Transarterial embolization for rare spontaneous subacute intratumoral hemorrhage of hepatic hemangioma: a case report and literature review

Jia¹,

Yin²,

Wang³

et al. 2022

Transl Cancer Res TCR

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Background: Intratumoral hemorrhage of hepatic hemangioma is very rare.Case Description: The case of a 54-year-old female with fever and anemia. Initial ultrasound was suggestive of liver abscess, but antibiotic treatment and blood transfusion did not alleviate the patient's symptoms. After abscess puncture and drainage, the patient was admitted to our hospital due to bleeding effusion. The diagnosis of hepatic hemangioma with subacute intratumoral hemorrhage was considered by enhanced magnetic resonance imaging (MRI). The patient's condition was managed with routine liver protection, anti-infection, fluid infusion and two transarterial embolization (TAE) sessions using pingyangmycin-lipiodol emulsion. After the treatment, the patient's symptoms were resolved, the body temperature was normal and the anemia was corrected. Subsequently, we continued periodic follow-up of the patient for four years. The patient was generally in good condition, and there were no symptoms related to hepatic hemangioma, such as fever and anemia. The volume of hepatic hemangioma was reduced by half, and the intratumoral hematoma was obviously absorbed.Conclusions: For patients with previous history of hemangioma, timely MRI can provide higher diagnostic accuracy after they develop symptoms such as fever and anemia. TAE is also a safe and reliable alternative to surgical resection.

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“…In female patients with adenomas less than 5 cm, a six-month period of observation with lifestyle changes, such as cessation of oral contraception, can be attempted. Continued growth is an indication for surgery [18]. Surgery is always indicated in male patients with adenomas regardless of size [19].…”

Section: Introductionmentioning

confidence: 99%

Liver Transplantation as a Treatment for Unresectable Hepatic Adenoma in a Patient With Abernethy Syndrome

Patel,

Thompson,

Sharshar

et al. 2024

Cureus

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Abernethy syndrome is a rare congenital anomaly characterized by an intrahepatic or extrahepatic portosystemic shunt. Most patients are asymptomatic; however, due to the alteration in, or lack of, a portovenous flow, patients with Abernethy syndrome are at high risk of developing sequelae of liver failure. Once these complications develop, the only definitive treatment is transplantation. Patients with Abernethy syndrome are also at a higher risk of developing benign and malignant liver lesions, including hepatic adenomas. Here, we describe the first case of deceased donor liver transplantation as a treatment for a patient with type 1 Abernethy syndrome complicated by large, unresectable hepatic adenoma, found to have focal hepatocellular carcinoma on pathologic examination. Our male patient was found to have elevated liver enzymes at age 33, during a routine outpatient medical appointment. Despite being asymptomatic, his history of prior liver resection prompted CT imaging, which revealed two large liver lesions concerning for hepatic adenomas. When surveillance imaging showed a significant growth of the liver lesions, biopsy was pursued, which confirmed a diagnosis of hepatic adenomas. However, given the size of these lesions, resection was not a viable option for the patient. Instead, the patient underwent liver transplantation at age 41, which he tolerated well. Our case demonstrates the utility of deceased donor liver transplantation as a treatment for patients with Abernethy syndrome complicated by unresectable adenomas.

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Scoping review of clinical practice guidelines on the management of benign liver tumours

Cited by 8 publications

References 60 publications

Etiology, Pathogenesis, Diagnosis, and Practical Implications of Hepatocellular Neoplasms

Etiology, Pathogenesis, Diagnosis, and Practical Implications of Hepatocellular Neoplasms

Transarterial embolization for rare spontaneous subacute intratumoral hemorrhage of hepatic hemangioma: a case report and literature review

Liver Transplantation as a Treatment for Unresectable Hepatic Adenoma in a Patient With Abernethy Syndrome

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