Scope and Need of Combination of Antihypertensive Drugs

Abstract

The recommendation for first-line therapy for hypertension remains a beta blocker or diuretic given in a low dosage. A target blood pressure of less than 140/90 mm Hg is achieved in about 50 percent of patients treated with monotherapy; two or more agents from different pharmacological classes are often needed to achieve adequate blood pressure control. Single-dose combination antihypertension therapyis an important option that combines efficacy of blood pressure reduction and a low side effect profilewith convenient once-daily dosing to enhance compliance. Combination antihypertensives include combined agents from the following pharmacological classes: diuretics and potassium-sparing diuretics,beta blockers and diuretics, angiotensin-converting enzyme (ACE) inhibitors and diuretics, angiotensin-II antagonists and diuretics and calcium channel blockers and ACE inhibitors.

Validated RP-HPLC method for the simultaneous determination of amlodipine besylate, valsartan, and hydrochlorothiazide in bulk and in pharmaceutical formulation

“…Various analytical methods have been reported for the assay of AMB alone or in combination with other anti-hypertensive agents in pharmaceutical formulations. They include UV spectroscopy [2][3][4], high-performance liquid chromatography (HPLC) [5][6][7][8], high-performance thin-layer chromatography (HPTLC) [9,10], LC-MS [11] and LC-MS/MS [12].…”