Scopadulcic acid-A and -B, new diterpenoids with a novel skeleton, from a Paraguayan crude drug “typychá kuratũ” ( L.)

Hayashi, Toshimitsu; Kishi, Mieko; Kawasaki, M.; Arisawa, Munehisa; Shimizu, Mineo; Suzuki, Shingo; Yoshizaki, Masao; Morita, Naokata; Tezuka, Yasuhiro; Kikuchi, Tohru; Berganza, Luis H.; Ferro, Esteban; Basualdo, Isabel

doi:10.1016/s0040-4039(00)96357-3

Cited by 65 publications

(26 citation statements)

References 2 publications

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“…Preliminary screening of endophytic fungi from medicinal plants in Malaysia for antimicrobial and antitumour activity [22] also supported this view. Similarly the production of camptothecin from the suspension cultures of Nothapodytis foetida was found to be enhanced by the presence of endophytic fungi [19].…”

Section: Resultsmentioning

confidence: 89%

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Endophytic Penicillium citrinum Thom. from Scoparia dulcis Linn

Mathew¹,

Jayachandran

Mathew

2010

Indian J Microbiol

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Scoparia dulcis of Scrophulariaceae is an annual herb distributed through out the tropics. Penicillium citrinum was obtained from apparently healthy roots, stem, leaves and fruits of this plant. Callus and multiple shoots produced during micropropagation from various explants were also symptomless but showed occurrence of Penicillium citrinum when cultured in Murashige & Skoog liquid medium for the production of secondary metabolites.

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Section: Resultsmentioning

confidence: 89%

“…The antitumorous [16] and antiviral properties [17] have also been reported. Phytochemical screening has revealed the presence of mainly diterpenes, triterpenes, fl avanoids and steroids [18][19].…”

Section: Introductionmentioning

confidence: 99%

Endophytic Penicillium citrinum Thom. from Scoparia dulcis Linn

Mathew¹,

Jayachandran

Mathew

2010

Indian J Microbiol

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“…(Scrophulariaceae) has been extensively studied for its flavone and terpene constituents (Ahmed et al, 1990, Ahsan et al, 2003, Chen et al, 1976, Hayashi et al, 1987, 1987b, Mahato et al, 1981, Nishino et al, 1993, Phan et al, 2006, Sitthithaworn et al, 2001, Taylor, 2005. A native of Central America, S. dulcis is now widely distributed in tropical America, Africa and Asia (Burkill, 2000).…”

Section: Scoparia Dulcismentioning

confidence: 99%

Hispidulin And Other Constituents Of Scoparia dulcis Linn

Osei‐Safo¹,

Chama²,

Addae‐Mensah³

et al. 2009

Jnl Sci Tech

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Phytochemical investigation of the ethanol extract of the whole plant of Scoparia dulcis, has resulted in the isolation of 4, 5, 7-trihydroxy-6-methoxyflavone, commonly called hispidulin and a steroidal glycoside, β-sitosterol-β-D-glucoside. This is the first isolation of the two compounds from S. dulcis. Also isolated and characterized were the previously reported 6-methoxybenzoxazolinone, friedelan-3-one and scopadulcic acid B. Structural elucidation was done on the basis of spectroscopic data interpretations (IR, UV, NMR and EIMS). Using the Tetrazolium-based colorimetric selective assay, hispidulin was found to be inactive against HIV-1/ IIIB in MT-4 cells whereas the same test on the aqueous extract of the plant was positive.

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“…already been isolated (Hayashi et a/., 1987(Hayashi et a/., , 1988. In order to elucidate the mode of action in the inhibition of virus replication, the effects of acacetin were studied under various conditions.…”

Section: Effects Of Flavanes On Cell Growth and Virus Replicationmentioning

confidence: 99%

Antiviral Agents of Plant Origin. Antiherpetic Activity of Acacetin

Hayashi

Arisawa

et al. 1993

Antivir Chem Chemother

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SummaryThe effect of acacetin isolated from Scoparia dulcis and several related flavonoids on herpes simplex virus type 1 (HSV-1) was studied in vitro by the method of plaque yield reduction. Among. -these compounds, acacetin was shown to be the m6st potent agent and caused dose-dependent inhibition of virus replication.-Acacetin had a weak virucidal activity at higher concentrations. Analysis of early events following infectionshowed that attachment of the virus to host cells and penetration were unaffected by acacetin. Acacetin was found to exert strong inhibition of protein synthesis in virus-infected cells but not in uninfected cells. The transcription of immediate-early genes and translation of their transcripts were in particular almost stopped by acacetin even at a lower concentration. These selective effects can be attributed mainly to the antiviral activity of acacetin.

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Scopadulcic acid-A and -B, new diterpenoids with a novel skeleton, from a Paraguayan crude drug “typychá kuratũ” ( L.)

Cited by 65 publications

References 2 publications

Endophytic Penicillium citrinum Thom. from Scoparia dulcis Linn

Endophytic Penicillium citrinum Thom. from Scoparia dulcis Linn

Hispidulin And Other Constituents Of Scoparia dulcis Linn

Antiviral Agents of Plant Origin. Antiherpetic Activity of Acacetin

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