Scoliosis and spinal deformities: twenty years of innovations

ZAINA, Fabio; WYNNE, James; COHEN, Larry

doi:10.23736/s1973-9087.23.08218-7

Cited by 3 publications

(3 citation statements)

References 13 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the results highlight the importance of ongoing research and the development of personalized intervention strategies for the appropriate management of spinal deformities in pediatric patients. Integrating physical therapy into a multidisciplinary approach could offer considerable benefits in improving spinal function and enhancing the quality of life for these patients [17][18]. Additionally, long-term identification and evaluation of the effects of this intervention can contribute to strengthening evidence and refining personalized therapeutic strategies, aiming to maximize benefits and optimize long-term outcomes for this vulnerable population [19].…”

Section: Discussionmentioning

confidence: 99%

"An Innovative Intervention Approach for Chronic Pain Management in Pediatric Static Vertebral Disorders through Physical Therapy"

LIMBALATA,

GEORGESCU,

ICONARU

2024

RJPT

View full text Add to dashboard Cite

"Introduction: In this study, we aimed to assess the effectiveness of a novel physical therapy intervention in managing chronic pain associated with pediatric static vertebral disorders. Methods and materials: The investigation encompassed both clinical variables, such as pain perception measured by a visual analog scale (VAS), and morpho-functional variables related to developmental level and spinal status: weight (W, kg), height (H, cm), body mass index (BMI), scapular/shoulder asymmetry (SA, cm), thoracolumbar fold asymmetry (TFA, cm), sacral dimples asymmetry (SDA, cm), intergluteal cleft deviation (ICD, cm), scoliosis measurement (SM, cm), right lumbar lateral flexion (RLLF, cm), left lumbar lateral flexion (LLLF, cm), and Cobb angle. The study involved a cohort of 48 subjects, aged between 8 and 12 years, who were divided into experimental and control groups. The experimental group underwent a six-month physical therapy-based rehabilitation program, while the control group did not receive any intervention during this period. Both groups underwent clinical and morpho-functional evaluations before and after the intervention. The analysis, conducted through a two-way repeated measures ANOVA, intended to explore the interaction between group and time of assessment on each dependent variable. Results: The results revealed significant differences in several variables (VAS scores, SA, TFA, SDA, ICD, SM, RLLF, LLLF, and Cobb angle) between the experimental and control groups (p ≤ 0.02), suggesting a discernible impact of the intervention on physiological and functional parameters related to spinal deformities and chronic pain management. Discussion: The intervention applied to the experimental group produced significant changes in key variables relevant for clinical assessment and morpho-functional analysis, indicating its notable impact on physiological and functional parameters. Conclusions: This study underscores the significant effect of tailored physical therapy interventions in mitigating chronic pain and improving morpho-functional aspects in pediatric spinal deformities."

show abstract

Section: Discussionmentioning

confidence: 99%

"An Innovative Intervention Approach for Chronic Pain Management in Pediatric Static Vertebral Disorders through Physical Therapy"

LIMBALATA,

GEORGESCU,

ICONARU

2024

RJPT

View full text Add to dashboard Cite

show abstract

“…Despite decades of research, the primary cause of AIS still remained uncertain and many arguments existed. 21 , 22 Among them, paraspinal muscular abnormities and neurological deficits played important roles, but how these factors drive scoliosis and interplay with each other were complicated and perplexing. 23 The NMJ was a peripheral synapse between motoneurons and skeletal muscle fibers that was critical to control muscle contractions.…”

Section: Discussionmentioning

confidence: 99%

The morphological discrepancy of neuromuscular junctions between bilateral paraspinal muscles in patients with adolescent idiopathic scoliosis: A quantitative immunofluorescence assay

Zhang,

Sui,

et al. 2024

JOR Spine

View full text Add to dashboard Cite

IntroductionPrior studies suggested that neuromuscular factors might be involved in the pathogenesis of adolescent idiopathic scoliosis (AIS). The neuromuscular junction (NMJ) is the important pivot where the nervous system interacts with muscle fibers, but it has not been well characterized in the paraspinal muscles of AIS. This study aims to perform the quantitative morphological analysis of NMJs from paraspinal muscles of AIS.MethodsAIS patients who received surgery in our center were prospectively enrolled. Meanwhile, age‐matched congenital scoliosis (CS) and non‐scoliosis patients were also included as controls. Fresh samples of paraspinal muscles were harvested intraoperatively. NMJs were immunolabeled using different antibodies to reveal pre‐synaptic neuronal architecture and post‐synaptic motor endplates. A confocal microscope was used to acquire z‐stack projections of NMJs images. Then, NMJs images were analyzed on maximum intensity projections using ImageJ software. The morphology of NMJs was quantitatively measured by a standardized ‘NMJ‐morph’ workflow. A total of 21 variables were measured and compared between different groups.ResultsA total of 15 AIS patients, 10 CS patients and 5 normal controls were enrolled initially. For AIS group, NMJs in the convex side of paraspinal muscles demonstrated obviously decreased overlap when compared with the concave side (34.27% ± 8.09% vs. 48.11% ± 10.31%, p = 0.0036). However, no variables showed statistical difference between both sides of paraspinal muscles in CS patients. In contrast with non‐scoliosis controls, both sides of paraspinal muscles in AIS patients demonstrated significantly smaller muscle bundle diameters.ConclusionsThis study first elucidated the morphological features of NMJs from paraspinal muscles of AIS patients. The NMJs in the convex side showed smaller overlap for AIS patients, but no difference was found in CS. This proved further evidence that neuromuscular factors might contribute to the mechanisms of AIS and could be considered as a novel potential therapeutic target for the treatment of progressive AIS.

show abstract

“…Data coming from observational studies are more challenging to manage and require more statistical knowledge and research skills. Nevertheless, because of the challenges 7 and ethical issues in PRM, 43 they are somehow more feasible and provide more clinically relevant findings. Standardized prospective data collection and registries could represent a decisive opportunity for future improvement of observational studies in PRM 44 …”

Section: Discussionmentioning

confidence: 99%

Observational Studies

Donzelli

Loss

Zaina

et al. 2022

Am J Phys Med Rehabil

Self Cite

View full text Add to dashboard Cite

The development of high-quality research is desired in all healthcare fields. Experimental and nonexperimental designs are used to investigate the effect or association of an intervention and clinical or surrogate outcome. The aims of these methods are to improve knowledge and to develop new strategies to manage a disease or condition. Randomized clinical trials are considered one of the standard methods to test the efficacy of a new drug or intervention; however, they are costly, have reduced generalizability, and cannot be feasible in all scenarios. Well-designed observational studies can provide valuable information regarding exposure factor and the event under investigation. In physical and rehabilitation medicine, where complex procedures and multiple risk factors can be involved in the same disease, the use of observational study must be planned in detail and a priori to avoid overestimations. In this article, we will give an overview of the methods used for observational design studies in physical and rehabilitation medicine using clinical examples to illustrate each method. We will describe when it is appropriate and how to use the observational studies in different scenarios explaining how to deal with potential bias and confounders using the adequate design and statistical plan for the situation.

show abstract

Scoliosis and spinal deformities: twenty years of innovations

Cited by 3 publications

References 13 publications

"An Innovative Intervention Approach for Chronic Pain Management in Pediatric Static Vertebral Disorders through Physical Therapy"

"An Innovative Intervention Approach for Chronic Pain Management in Pediatric Static Vertebral Disorders through Physical Therapy"

The morphological discrepancy of neuromuscular junctions between bilateral paraspinal muscles in patients with adolescent idiopathic scoliosis: A quantitative immunofluorescence assay

Observational Studies

Contact Info

Product

Resources

About