Sclerotherapy for hydrocele revisited: a prospective randomised study

Agrawal, Mukul; Yadav, Himanshu; Upadhyay, Ashish Datt; Jaiman, Richa; Singhal, Jyotsana; Singh, Anuj Kumar

doi:10.1007/s12262-009-0006-7

Cited by 13 publications

(15 citation statements)

References 14 publications

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“…Furthermore, the rate of SES in the group without AAAM was comparable to previous findings . In randomised studies, complications included oedema, haematoma and infections were seen in 5–10% of the patients and similarly so in other studies using polidocanol and doxycycline . In none of these studies was SES studied or mentioned, but pain was reported to occur in 9–70% of the cases .…”

Section: Discussionsupporting

confidence: 84%

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Modulation of the inflammatory response after sclerotherapy for hydrocoele/spermatocoele

2018

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Objective To investigate the modulation of the inflammatory response after sclerotherapy for hydrocoele/spermatocoele. Patients and Methods All patients with hydrocoele or spermatocoele presenting at the Department of Urology, University Hospital, Linköping, Sweden, from 2006 to 2012, were included in this prospective observational study of sclerotherapy for hydrocoele/spermatocoele using polidocanol as a sclerosing agent and adjuvant antibiotic and anti‐inflammatory medication (AAAM) for modulation of the inflammatory response. Patients were clinically evaluated within 24–48 h after a complication or adverse event possibly related to sclerotherapy. Evaluation of cure was scheduled after 3 months and re‐treatment, if necessary was carried out in the same manner as the first treatment. Groups of patients were compared using the chi‐squared test and logistic regression analysis. Results From a total of 191 patients, AAAM was given to 126, of whom 5% had subclinical epididymitis/swelling (SES) compared to 26% of the patients without AAAM (P < 0.001). No other complication was observed. The rate of cure for the whole group of patients was 93% after one or two treatments and significantly higher in the group with AAAM than in the group without AAAM (96% vs 88%, P = 0.03). Conclusions Modulation of the inflammatory response after sclerotherapy resulted in a lower incidence of SES and an increased cure rate.

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Section: Discussionsupporting

confidence: 84%

“…Cure after one treatment was also more common in patients with smaller coele, as noted previously by others . The definition of smaller coele differed between different studies, and the size of the coele (i.e., emptied volume) was not accounted for in many analyses, making comparison between studies difficult .…”

Section: Discussionmentioning

confidence: 65%

Modulation of the inflammatory response after sclerotherapy for hydrocoele/spermatocoele

2018

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“…Similarly, Fuse et al [18] reported none of their 15 patients to be having bilateral involvement. Agrawal et al [19] also did not report a single case with bilateral involvement. It is difficult to comment whether all these studies had selected patients with unilateral involvement only, as these studies were comparative studies, and hence, in order to rule out any confounding effect, they might have excluded the bilateral involvement.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of the Role of Sodium Tetradecyl Sulfate as a Sclerosant in the Treatment of Primary Hydrocele

et al. 2013

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The present study was carried out with an aim to perform a prospective study to establish the role of sodium tetradecyl sulfate (3 %) (STDS) as a safe and effective sclerosant in the management of primary hydrocele. Sclerotherapy was performed with 3 % STDS on an outdoor basis. The amount of sclerosant injected depended on the amount of fluid drained. All patients were given prophylactic antibiotics. Patients were clinically reassessed at 1 week, 1 month, 3 months, and 6 months and earlier if complications occur. The data were analyzed using Statistical Package for Social Sciences Version 15.0. The data have been represented as frequencies and percentages. Chi-square test was used to compare the data. A total of 57 patients with primary vaginal hydrocele gave consent for being enrolled in the study. The age of patients ranged from 18 to 65 years with a mean age of 35.72±13.18 years. The success rate at the end of the study was observed to be 84.2 %. As regards patient satisfaction, in present study, in a limited time period of follow up, all the patients who had a successful procedure were satisfied. Overall, sclerotherapy was observed to be a relatively cost-effective (including both direct and indirect costs) procedure with low complications, high satisfaction, and a high success rate within the limited period of follow-up.

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“…Each agent reports a cure rate ranging from 85% to 97%, with complication rates of up to 50%. [8][9][10][11][12] Alcohol is a sclerosing agent that has a chemical irritant effect on the contacting tissue. The necrosis produced by alcohol injection is secondary to cellular dehydration, cell membrane lysis, and protein denaturation.…”

Section: Discussionmentioning

confidence: 99%

The use of TPA in combination with alcohol in the treatment of the recurrent complex hydrocele

Metcalfe

Spouge

et al. 2014

CUAJ

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A hydrocele is an abnormal collection of serous fluid in the space between the parietal and visceral layers of the tunica vaginalis. Hydrocele is the most common cause of painless scrotal swelling which affects about 1% of men. Generally, adult hydroceles are idiopathic in origin; however, inguinal surgery, varicocelectomy, infection, trauma and a patent processus vaginalis are each associated with the subsequent development of a hydrocele. Surgical removal of hydroceles is the gold standard of care. However, multiple cases have reported high success rates (ranging from 85% to 96%) using a combination of aspiration and sclerotherapy. We present a case of a patient with recurring complex hydrocele and effective treatment utilizing a combination of thrombolytic therapy, catheter drainage and subsequent alcohol ablation.

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Sclerotherapy for hydrocele revisited: a prospective randomised study

Abstract: Five percent phenol is a better sclerosant than 1% polidocanol and is as efficacious as operative treatment, with lesser morbidity and similar safety profile.

Cited by 13 publications

References 14 publications

Modulation of the inflammatory response after sclerotherapy for hydrocoele/spermatocoele

Modulation of the inflammatory response after sclerotherapy for hydrocoele/spermatocoele

Evaluation of the Role of Sodium Tetradecyl Sulfate as a Sclerosant in the Treatment of Primary Hydrocele

The use of TPA in combination with alcohol in the treatment of the recurrent complex hydrocele

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